Benzoic acid, 3,4,5-tris[[(1,1-dimethylethoxy)carbonyl]oxy]- | 803737-15-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzoic acid, 3,4,5-tris[[(1,1-dimethylethoxy)carbonyl]oxy]-
• 英文别名: 3,4,5-tris[(2-methylpropan-2-yl)oxycarbonyloxy]benzoic acid
• CAS: 803737-15-7
• 化学式: C₂₂H₃₀O₁₁
• 分子量: 470.5
• InChiKey: SQKBRIYKGXDUCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  33
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  144
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• Polyhydroxy phenols and their use in binding p-selectin
  申请人：Biessen Leonardus Erik Anna

  公开号：US20060276545A1

  公开（公告）日：2006-12-07

  Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, and a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as polyhydroxy phenol-containing pharmaceutical and nutraceutical compositions. The use of polyhydroxy phenols as a medicament and especially for the manufacture of a medicament for the prevention, treatment or diagnosis of a disease or a condition, wherein P-selectin is involved, is provided. The same compounds can also be used as targeting tools to P-selectin expressing cells or tissues in a composition, further comprising an active compound in a vehicle.

  本发明提供了多羟基酚，其是没肽基的没食子酸肽类似物，并提供了使用提供没食子酸基团的方法制备没食子酸衍生物，以及含有多羟基酚的药用和营养成分组合物。本发明还提供了将多羟基酚用作药物，特别是用于制造用于预防、治疗或诊断涉及P选择素的疾病或病症的药物。同样的化合物也可用作定向工具，用于在组合物中靶向表达P选择素的细胞或组织，进一步包括载体中的活性化合物。
• POLYHYDROXY PHENOLS AND THEIR USE IN BINDNG P-SELECTIN
  申请人：Astellas Pharma Inc.

  公开号：EP1651200A1

  公开（公告）日：2006-05-03
• GALLOYLPEPTIDES
  申请人：Astellas Pharma Inc.

  公开号：EP1651200B1

  公开（公告）日：2008-12-24
• US7273951B2
  申请人：——

  公开号：US7273951B2

  公开（公告）日：2007-09-25
• [EN] POLYHYDROXY PHENOLS AND THEIR USE IN BINDNG P-SELECTIN<br/>[FR] POLYHYDROXY PHENOLS ET LEUR UTILISATION POUR LIER LA P-SELECTINE
  申请人：YAMANOUCHI PHARMA CO LTD

  公开号：WO2004105740A1

  公开（公告）日：2004-12-09

  Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, and a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as polyhydroxy phenol-containing pharmaceutical and nutraceutical compositions. The use of polyhydroxy phenols as a medicament and especially for the manufacture of a medicament for the prevention, treatment or diagnosis of a disease or a condition, wherein P-selectin is involved, is provided. The same compounds can also be used as targeting tools to P-selectin expressing cells or tissues in a composition, further comprising an active compound in a vehicle.