A-423579 | 461045-17-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: A-423579
• 英文别名: 4'-{3-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]propoxy}-3',5'-difluoro-1,1'-biphenyl-4-carbonitrile；Q2CW3V5Wgf；4-[4-[3-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]propoxy]-3,5-difluorophenyl]benzonitrile
• CAS: 461045-17-0
• 化学式: C₂₂H₂₅F₂N₃O
• 分子量: 385.457
• InChiKey: DJXFZKXYKKBTDR-LJQANCHMSA-N

物化性质

• 沸点：
  529.0±50.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  39.5
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
  申请人：——

  公开号：US20020137931A1

  公开（公告）日：2002-09-26

  Compounds of formula I 1 are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclosed are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.

  公式I1的化合物在治疗由组胺-3受体配体防止或改善的疾病或症状中很有用。还披露了组胺-3受体配体组合物和拮抗或激动组胺-3受体的方法。
• [EN] 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS<br/>[FR] PYRROLIDINES 1,3-DISUBSTITUEES ET 1,3,3,-TRISUBSTITUEES UTILISEES COMME LIGANDS DU RECEPTEUR DE L'HISTAMINE-3 ET APPLICATIONS THERAPEUTIQUES
  申请人：ABBOTT LAB

  公开号：WO2003059341A1

  公开（公告）日：2003-07-24

  Compounds of formula I, are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclosed are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.

  式I的化合物可用于治疗由组胺-3受体配体预防或改善的疾病或病况。本发明还揭示了组胺-3受体配体组合物和拮抗或激动组胺-3受体的方法。
• 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS
  申请人：Abbott Laboratories

  公开号：EP1467727A1

  公开（公告）日：2004-10-20
• US6620839B2
  申请人：——

  公开号：US6620839B2

  公开（公告）日：2003-09-16