N,N'-bis((R)-1-phenylethyl)-(S,S)-4,5-diamine-1,7-octadiene | 138812-18-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-bis((R)-1-phenylethyl)-(S,S)-4,5-diamine-1,7-octadiene
• 英文别名: N,N'-Bis(1-phenylethyl)-1,7-octadiene-4-(S),5(S)-diamine；(4S,5S)-4-N,5-N-bis[(1R)-1-phenylethyl]octa-1,7-diene-4,5-diamine
• CAS: 138812-18-7
• 化学式: C₂₄H₃₂N₂
• 分子量: 348.531
• InChiKey: ATZFBNIGZKFWRG-CHOVIJNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-bis((R)-1-phenylethyl)-(S,S)-4,5-diamine-1,7-octadiene 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 生成 (4S,5S)-辛烷-4,5-二胺
  参考文献：
  名称：

  The stereoselective synthesis of functionalized vicinal diamine systems by the double allylation reactions of “protected” 1,2-bis-imine precursors.

  摘要：

  A diastereoselective synthesis of vicinal diamines via the reactions of allylic Grignard reagents with readily available "protected" 1,2-bisimines has been developed. This method has been extended to preparing optically pure diamines by the use of chiral 1,2-bisimine precursors.

  DOI：

  10.1016/s0040-4039(00)79412-3
• 作为产物：
  描述：

  氯丙烯镁 、 Benzenemethanamine, N,N'-1,2-ethanediylidenebis[α-methyl-, [N(E),N'(E),αR,α'R]-rel- 以 四氢呋喃 为溶剂， 生成 N,N'-bis((R)-1-phenylethyl)-(S,S)-4,5-diamine-1,7-octadiene 、 (4R,5R)-N,N'-Bis-((R)-1-phenyl-ethyl)-octa-1,7-diene-4,5-diamine
  参考文献：
  名称：

  The stereoselective synthesis of functionalized vicinal diamine systems by the double allylation reactions of “protected” 1,2-bis-imine precursors.

  摘要：

  A diastereoselective synthesis of vicinal diamines via the reactions of allylic Grignard reagents with readily available "protected" 1,2-bisimines has been developed. This method has been extended to preparing optically pure diamines by the use of chiral 1,2-bisimine precursors.

  DOI：

  10.1016/s0040-4039(00)79412-3

文献信息

• Synthesis and Coordination Chemistry of <i>N,N</i>-Diallylbispidine
  作者：Huiling Cui、Richard Goddard、Klaus-Richard Pörschke

  DOI：10.1021/om200824c

  日期：2011.11.28

  monomeric C7H12N2(C3H5)CH═CHCH2}PtCl (13a), and the presence of MeOH afforded C7H12N2(C3H5)CH2CH(OMe)CH2}PtCl (13b), both compounds featuring novel anionic tridentate ligands. Furthermore, chiral N,N′-bis((R)-1-phenylethyl)-1,7-octadiene-(S,S)-4,5-diamine (15) reacts with CuI to give [(C3H5)2C2H4N2(CHMePh)2}Cu(μ-I)]2 (16). The unbound N-allyl functions on the ligands in the product complexes allow

  3,7-二烯丙基-3,7-二氮杂二环[3.3.1]壬烷（C的合成7 ħ 12 Ñ 2烯丙基2，3）已被重新，并且几个迄今未检测到的副产物也已确定。通过制备型GC和柱色谱法分离纯3和这些副产物。单质子化3以PF 6盐[（C 7 H 13 N 2烯丙基2 ] PF 6（9）的形式存在，以及3与Ni（acac）2和CuI的加成络合物（C 7 H 12 N制备了2烯丙基2）Ni（acac）2（10）和（C 7 H 12 N 2烯丙基2）Cu（μ-I）} 2（11）。从（η的反应3 -C 3 H ^ 5）M（μ-X）} 2（M =镍，钯，铂; X =氯，溴）与3和TlPF 6的配合物[（C 7 H ^ 12 ñ 2烯丙基2）M（η 3 -C 3 H ^ 5）] PF 6（M =镍（12A），得到Pd（12b），Pt（12c））。化合物9 - 11和12b中通过X-射线晶体学进行了表征。（1，5-己二烯）PtCl
• Solubilized zirconocene dihydride as a promotor of alkene coupling reactions
  作者：Peter Wipf、Xiaodong Wang

  DOI：10.1016/s0040-4039(00)01468-4

  日期：2000.10

  The THF-soluble bis(methoxyethyl)zirconocene dihydride 3 displayed novel reactivity patterns and was used to reductively couple alkenes, dienes, and enynes. A plausible mechanism involves the formation of a 14-electron zirconium(II) and zirconacyclopentane species. (C) 2000 Published by Elsevier Science Ltd.
• The stereoselective synthesis of functionalized vicinal diamine systems by the double allylation reactions of “protected” 1,2-bis-imine precursors.
  作者：William L. Neumann、Milorad M. Rogic、T.Jeffrey Dunn

  DOI：10.1016/s0040-4039(00)79412-3

  日期：1991.10

  A diastereoselective synthesis of vicinal diamines via the reactions of allylic Grignard reagents with readily available "protected" 1,2-bisimines has been developed. This method has been extended to preparing optically pure diamines by the use of chiral 1,2-bisimine precursors.