(2S,3R)-2-benzyl-3-prop-2-enoxypentanoic acid | 460352-51-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (2S,3R)-2-benzyl-3-prop-2-enoxypentanoic acid
• CAS: 460352-51-6
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: JEVDWGKWLDSWTR-UONOGXRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2S,3R)-2-benzyl-3-prop-2-enoxypentanoic acid 在 盐酸 、 叠氮磷酸二苯酯 作用下， 以 水 为溶剂， 生成 (2S,3R)-1-phenyl-3-prop-2-enoxypentan-2-amine
  参考文献：
  名称：

  Synthesis of Cyclic Peptidomimetics from Aldol Building Blocks

  摘要：

  Aldol products (3-hydroxy acids) with an allylprotected hydroxy group were converted to amino alcohols by Curtius rearrangement. Combination of the carboxylic acid with the amino alcohols gave the amides 10. Ring-closing metathesis led to the 12-membered lactams 12 as mixtures of E/Z-isomers. The scheme was also transferred to the solid-phase. In this case the macrolactams are formed via cyclorelease. For a pair of E/Z-isomers the solution conformation was determined by ROESY spectroscopy.

  DOI：

  10.1021/jo025889b
• 作为产物：
  描述：

  (S)-4-苄基-3-(3-苯基丙酰基)噁唑烷丁-2-酮 在 lithium hydroxide 、 三氟甲磺酸 、 三氟甲磺酸二丁硼 、 双氧水 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 环己烷 、 水 为溶剂， 反应 8.5h， 生成 (2S,3R)-2-benzyl-3-prop-2-enoxypentanoic acid
  参考文献：
  名称：

  Synthesis of Cyclic Peptidomimetics from Aldol Building Blocks

  摘要：

  Aldol products (3-hydroxy acids) with an allylprotected hydroxy group were converted to amino alcohols by Curtius rearrangement. Combination of the carboxylic acid with the amino alcohols gave the amides 10. Ring-closing metathesis led to the 12-membered lactams 12 as mixtures of E/Z-isomers. The scheme was also transferred to the solid-phase. In this case the macrolactams are formed via cyclorelease. For a pair of E/Z-isomers the solution conformation was determined by ROESY spectroscopy.

  DOI：

  10.1021/jo025889b

文献信息

• Synthesis of Cyclic Peptidomimetics from Aldol Building Blocks
  作者：Sanjita Sasmal、Armin Geyer、Martin E. Maier

  DOI：10.1021/jo025889b

  日期：2002.8.1

  Aldol products (3-hydroxy acids) with an allylprotected hydroxy group were converted to amino alcohols by Curtius rearrangement. Combination of the carboxylic acid with the amino alcohols gave the amides 10. Ring-closing metathesis led to the 12-membered lactams 12 as mixtures of E/Z-isomers. The scheme was also transferred to the solid-phase. In this case the macrolactams are formed via cyclorelease. For a pair of E/Z-isomers the solution conformation was determined by ROESY spectroscopy.