ethyl (3S,5S)-2-[bis(4-methoxyphenyl)methyl]-5-[(1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.01,5]decane-4-carbonyl]-1,2-oxazolidine-3-carboxylate | 185522-68-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl (3S,5S)-2-[bis(4-methoxyphenyl)methyl]-5-[(1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.01,5]decane-4-carbonyl]-1,2-oxazolidine-3-carboxylate
• 英文别名: ethyl (3S,5S)-2-[bis(4-methoxyphenyl)methyl]-5-[(1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-azatricyclo[5.2.1.01,5]decane-4-carbonyl]-1,2-oxazolidine-3-carboxylate
• CAS: 185522-68-3
• 化学式: C₃₂H₄₀N₂O₈S
• 分子量: 612.744
• InChiKey: GHRLEIRKFDXHOT-ZEOKNKPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  43
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  120
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  ethyl (3S,5S)-2-[bis(4-methoxyphenyl)methyl]-5-[(1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.01,5]decane-4-carbonyl]-1,2-oxazolidine-3-carboxylate 在 lithium hydroxide 、 双氧水 、 copper(l) chloride 作用下， 以 水 为溶剂， 反应 16.0h， 生成 (3S,5S)-2-[Bis-(4-methoxy-phenyl)-methyl]-isoxazolidine-3,5-dicarboxylic acid 5-tert-butyl ester 3-ethyl ester
  参考文献：
  名称：

  Asymmetric 1,3-dipolar cycloaddition: Synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester

  摘要：

  An asymmetric synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester is described. The key feature of the synthesis is the asymmetric 1,3-dipolar cycloaddition of nitrone 4 with 5, which provides stereoselectively the isoxazolidine with the correct stereochemistry suitable for the synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester 1. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0957-4166(96)00407-7
• 作为产物：
  描述：

  4,4'-dimethoxybenzophenone oxime 在 盐酸 、 吡啶硼烷 作用下， 以 乙醇 、 甲苯 、 苯 为溶剂， 反应 36.5h， 生成 ethyl (3S,5S)-2-[bis(4-methoxyphenyl)methyl]-5-[(1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3lambda6-thia-4-azatricyclo[5.2.1.01,5]decane-4-carbonyl]-1,2-oxazolidine-3-carboxylate
  参考文献：
  名称：

  Asymmetric 1,3-dipolar cycloaddition: Synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester

  摘要：

  An asymmetric synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester is described. The key feature of the synthesis is the asymmetric 1,3-dipolar cycloaddition of nitrone 4 with 5, which provides stereoselectively the isoxazolidine with the correct stereochemistry suitable for the synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester 1. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0957-4166(96)00407-7

文献信息

• Asymmetric 1,3-dipolar cycloaddition: Synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester
  作者：Thierry Geffaut、Udo Bauer、Karri Airola、Ari M.P. Koskinen

  DOI：10.1016/0957-4166(96)00407-7

  日期：1996.11

  An asymmetric synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester is described. The key feature of the synthesis is the asymmetric 1,3-dipolar cycloaddition of nitrone 4 with 5, which provides stereoselectively the isoxazolidine with the correct stereochemistry suitable for the synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester 1. Copyright (C) 1996 Elsevier Science Ltd