((R)-1-Chloro-2-phenyl-ethyl)-phosphonic acid | 132009-11-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ((R)-1-Chloro-2-phenyl-ethyl)-phosphonic acid
• 英文别名: [(1R)-1-chloro-2-phenylethyl]phosphonic acid
• CAS: 132009-11-1
• 化学式: C₈H₁₀ClO₃P
• 分子量: 220.592
• InChiKey: CBPWBILYTDGNHB-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (1R,2S,4R,6R,7S)-4-((R)-1-Chloro-2-phenyl-ethyl)-5-isopropyl-1,10,10-trimethyl-3-oxa-5-aza-4-phospha-tricyclo[5.2.1.0^2,6]decane 4-oxide 在 盐酸 作用下， 以 四氢呋喃 为溶剂， 生成 ((R)-1-Chloro-2-phenyl-ethyl)-phosphonic acid
  参考文献：
  名称：

  Camphor-based oxazaphospholanes as chiral templates for the enantioselective synthesis of α-chlorophosphonic acids

  摘要：

  Constrained camphor-derived oxazaphospholanes have provided an efficient entry for the preparation of enantiomerically enriched alpha-chlorophosphonic acids. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00455-3

文献信息

• The asymmetric synthesis of α-chloro α-alkyl and α-methyl α-alkyl phosphonic acids of high enantiomeric purity.
  作者：Stephen Hanessian、Youssef L. Bennani、Daniel Delorme

  DOI：10.1016/s0040-4039(00)97091-6

  日期：1990.1

  A method is described for the synthesis of α-chloro-α-alkyl- and α-methyl-α-alkylphosphonic acids in either enantiomeric form and in high optical purity, based on the asymmetric alkylation of α-substituted bicyclic phosphonamides derived from a C2 symmetrical diamine.

  描述了一种基于衍生自C的α-取代的双环膦酰胺的不对称烷基化合成对映体形式和高光学纯度的α-氯-α-烷基-和α-甲基-α-烷基膦酸的方法2对称的二胺。
• Camphor-based oxazaphospholanes as chiral templates for the enantioselective synthesis of α-chlorophosphonic acids
  作者：Giovanni Battista Giovenzana、Roberto Pagliarin、Giovanni Palmisano、Tullio Pilati、Massimo Sisti

  DOI：10.1016/s0957-4166(99)00455-3

  日期：1999.11

  Constrained camphor-derived oxazaphospholanes have provided an efficient entry for the preparation of enantiomerically enriched alpha-chlorophosphonic acids. (C) 1999 Elsevier Science Ltd. All rights reserved.