7-Bromo-4-(toluene-4-sulfonyl)-3,4-dihydro-1H-thieno[3,4-b]indole 2,2-dioxide | 210908-49-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 7-Bromo-4-(toluene-4-sulfonyl)-3,4-dihydro-1H-thieno[3,4-b]indole 2,2-dioxide
• 英文别名: 7-Bromo-4-(4-methylphenyl)sulfonyl-1,3-dihydrothieno[3,4-b]indole 2,2-dioxide
• CAS: 210908-49-9
• 化学式: C₁₇H₁₄BrNO₄S₂
• 分子量: 440.338
• InChiKey: ZAUPXSUCRZVNMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  90
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-苯基马来酰亚胺 、 7-Bromo-4-(toluene-4-sulfonyl)-3,4-dihydro-1H-thieno[3,4-b]indole 2,2-dioxide 以 甲苯 为溶剂， 反应 2.0h， 以76%的产率得到8-Bromo-2-phenyl-5-(toluene-4-sulfonyl)-4,5,10,10a-tetrahydro-3aH-pyrrolo[3,4-b]carbazole-1,3-dione
  参考文献：
  名称：

  Preparation and Reactions of Benzofurano-, Indolo-, and Benzothieno-3-sulfolenes

  摘要：

  Benzofurano-, N-tosylindolo-, and benzothieno-3-sulfolenes have been prepared efficiently via their dihydro analogues. These fused 3-sulfolenes serve as ideal precursors for the corresponding heteroaromatic o-quinodimethanes. Derivatives of these 3-sulfolenes bearing bromo or alkyl group substitution from which substituted heteroaromatic o-quinodimethanes are generated have also been synthesized.

  DOI：

  10.1021/jo980044e
• 作为产物：
  描述：

  (1,1-Dioxo-2,3-dihydro-1H-1λ⁶-thiophen-3-yl)-(2-iodo-phenyl)-amine 在 偶氮二异丁腈 、 溴 、 三正丁基氢锡 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 苯 为溶剂， 反应 71.0h， 生成 7-Bromo-4-(toluene-4-sulfonyl)-3,4-dihydro-1H-thieno[3,4-b]indole 2,2-dioxide
  参考文献：
  名称：

  Preparation and Reactions of Benzofurano-, Indolo-, and Benzothieno-3-sulfolenes

  摘要：

  Benzofurano-, N-tosylindolo-, and benzothieno-3-sulfolenes have been prepared efficiently via their dihydro analogues. These fused 3-sulfolenes serve as ideal precursors for the corresponding heteroaromatic o-quinodimethanes. Derivatives of these 3-sulfolenes bearing bromo or alkyl group substitution from which substituted heteroaromatic o-quinodimethanes are generated have also been synthesized.

  DOI：

  10.1021/jo980044e

文献信息

• Preparation and Reactions of Benzofurano-, Indolo-, and Benzothieno-3-sulfolenes
  作者：Chung-Wen Ko、Ta-shue Chou

  DOI：10.1021/jo980044e

  日期：1998.7.1

  Benzofurano-, N-tosylindolo-, and benzothieno-3-sulfolenes have been prepared efficiently via their dihydro analogues. These fused 3-sulfolenes serve as ideal precursors for the corresponding heteroaromatic o-quinodimethanes. Derivatives of these 3-sulfolenes bearing bromo or alkyl group substitution from which substituted heteroaromatic o-quinodimethanes are generated have also been synthesized.