N,N-dibutyl-P,P-diphenylphosphinic amide | 63528-20-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-dibutyl-P,P-diphenylphosphinic amide
• 英文别名: Phosphinic amide, N,N-dibutyl-P,P-diphenyl-；N-butyl-N-diphenylphosphorylbutan-1-amine
• CAS: 63528-20-1
• 化学式: C₂₀H₂₈NOP
• 分子量: 329.422
• InChiKey: LVYURLOFBFOZIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N,N-dibutyl-P,P-diphenylphosphinous amide 在 作用下， 生成 N,N-dibutyl-P,P-diphenylphosphinic amide
  参考文献：
  名称：

  氮中心自由基的亲核取代：通过S RN 1机理，二苯基磷离子与N，N-二丁基-对甲苯磺酰胺的反应

  摘要：

  的光刺激反应Ñ，Ñ -dibutyl- p -toluenesulfonamide与液态氨二苯基磷化引线离子为相应的次膦酰胺后，用氧化抑制实验p -dinitrobenzene和2,2,6,6-四甲基-1-哌啶氧基自由基（ TEMPO）以及反应在黑暗中被延迟的事实表明它是通过S RN 1机理进行的。

  DOI：

  10.1002/poc.610080507

文献信息

• Practical Synthesis of Phosphinic Amides/Phosphoramidates through Catalytic Oxidative Coupling of Amines and P(O)−H Compounds
  作者：Chen Tan、Xinyuan Liu、Huanxin Jia、Xiaowen Zhao、Jian Chen、Zhiyong Wang、Jiajing Tan

  DOI：10.1002/chem.201904237

  日期：2020.1.16

  Herein, we report a highly efficient ZnI2 -triggered oxidative cross-coupling reaction of P(O)-H compounds and amines. This operationally simple protocol provides unprecedented generic access to phosphinic amides/phosphoramidate derivatives in good yields and short reaction time. Besides, the reaction proceeds under mild conditions, which avoids the use of hazardous reagents, and is applicable to scale-up

  在本文中，我们报告了P​​（O）-H化合物与胺类的高效ZnI2触发的氧化交叉偶联反应。该操作简单的方案以高收率和较短的反应时间提供了对次膦酰胺/氨基磷酸酯衍生物的空前通用访问。此外，该反应在温和的条件下进行，避免了使用有害试剂，并且适用于按比例放大的合成以及药物分子的后期功能化。立体特异性偶联也可以从容易获得的光学富集的P（O）-H化合物中获得。
• ORGANIC PHOSPHORUS COMPOUNDS 106.¹ A ³¹P-NMR STUDY OF PHOSPHINOUS-, PHOSPHINIC-, AND THIOPHOSPHINIC AMIDES
  作者：Ludwig Maier、Peter J. Diel

  DOI：10.1080/10426509608037973

  日期：1996.8.1

  Abstract The synthesis, physical, chemical and spectroscopic properties of eight different types of phosphinous-, phosphinic- and thiophosphinic amides are reported. It is shown that the 31P-chem. shifts of tertiary amides are at lower magnetic field than that of secondary amides. As an exception, in the bis(tertiary butyl) series this trend is reversed.

  摘要 报道了八种不同类型的次膦酰胺、次膦酰胺和硫代次膦酰胺的合成、物理、化学和光谱性质。结果表明，31P-chem. 叔酰胺的位移磁场低于仲酰胺的磁场。作为一个例外，在双（叔丁基）系列中，这种趋势发生了逆转。
• Primary Amination of Ar₂P(O)–H with (NH₄)₂CO₃ as an Ammonia Source under Simple and Mild Conditions and Its Extension to the Construction of Various P–N or P–O Bonds
  作者：Yushi Tan、Ya-Ping Han、Yuecheng Zhang、Hong-Yu Zhang、Jiquan Zhao、Shang-Dong Yang

  DOI：10.1021/acs.joc.1c02933

  日期：2022.3.4

  reagents with stable and readily available ammonium carbonate as an ammonia source is disclosed herein for the first time. This ethyl bromoacetate-mediated primary amination proceeds smoothly under mild and simple conditions, without any metal catalyst or oxidant. Moreover, this method is also appropriate for the reaction of Ar2P(O)–H with a variety of amines, alcohols, and phenols to construct P–N or P–O

  本文首次公开了一种简便有效的方法，用于从 Ar 2 P(O)-H 试剂与稳定且易于获得的碳酸铵作为氨源合成伯膦酰胺。这种溴乙酸乙酯介导的伯胺化在温和简单的条件下顺利进行，无需任何金属催化剂或氧化剂。此外，该方法还适用于Ar 2 P(O)-H与多种胺类、醇类和酚类反应构建P-N或P-O键，操作方便，官能团耐受性好。 ，和广泛的底物范围。
• Nucleophilic substitution at nitrogen-centered radicals: Reactions of diphenylphosphide ions with<i>N</i>,<i>N</i>-dibutyl-<i>p</i>-toluenesulfonamide by the<i>S</i>_RN1 mechanism
  作者：Gabriela S. Foray、Alicia B. Peñéñory、Roberto A. Rossi

  DOI：10.1002/poc.610080507

  日期：1995.5

  The photostimulated reaction of N,N-dibutyl-p-toluenesulfonamide with diphenylphosphide ions in liquid ammonia leads to the corresponding phosphinic amides after oxidation Inhibition experiments with p-dinitrobenzene and 2,2,6,6-tetramethyl-1-piperidinyloxy free radical (TEMPO) and the fact that the reaction is retarded in the dark suggest that it proceeds by the SRN1 mechanism.

  的光刺激反应Ñ，Ñ -dibutyl- p -toluenesulfonamide与液态氨二苯基磷化引线离子为相应的次膦酰胺后，用氧化抑制实验p -dinitrobenzene和2,2,6,6-四甲基-1-哌啶氧基自由基（ TEMPO）以及反应在黑暗中被延迟的事实表明它是通过S RN 1机理进行的。
• Immunoassay method
  申请人：Ohzeki Katsuhisa

  公开号：US20080145869A1

  公开（公告）日：2008-06-19

  The present invention provides a method for immunoassaying an object to be analyzed including: causing to act, on a specimen or a sample including the specimen, a first protein (Y), which can specifically recognize the object to be analyzed in the specimen and is modified by a labeling substance, so as to form a complex including the object to be analyzed and Y; and measuring the labeling substance contained in the complex or the labeling substance contained in the free protein (Y), wherein the measurement of the labeling substance is performed by a chemiluminescent method which includes sensing the light generated by chemiluminescence using a photothermographic material including at least an organic silver salt, a reducing agent for silver ions and a photosensitive silver halide to form a latent image, and making the latent image visible by thermal development. An easy, quick, and highly precise immunoassay method is provided.

  本发明提供了一种免疫分析待分析物的方法，包括：在含有待分析物的样本或标本上作用第一蛋白（Y），该蛋白可以特异性地识别标本中的待分析物并被标记物质改性，以形成包括待分析物和Y的复合物；并测量复合物中包含的标记物质或自由蛋白（Y）中包含的标记物质。其中，标记物质的测量是通过化学发光法进行的，该法包括使用至少含有有机银盐、银离子还原剂和感光银卤化物的光热材料来感应化学发光所产生的光，并通过热发展使潜像可见。提供了一种简单、快速、高精度的免疫分析方法。