3-[(2-甲基丁酰基)氨基]苯甲酸 | 890983-61-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-[(2-甲基丁酰基)氨基]苯甲酸
• 英文名称: 3-[(2-Methylbutanoyl)amino]benzoic acid
• 英文别名: 3-(2-methylbutanoylamino)benzoic acid
• CAS: 890983-61-6
• 化学式: C₁₂H₁₅NO₃
• 分子量: 221.25
• InChiKey: YMBLRAJBSUMZCE-UHFFFAOYSA-N

物化性质

• 沸点：
  445.1±28.0 °C(Predicted)
• 密度：
  1.196±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2924299090

文献信息

• Process for synthesizing carbapenem using raney nickel
  申请人：ACS DOBFAR S.p.A.

  公开号：EP2141167A1

  公开（公告）日：2010-01-06

  Convenient method for obtaining carbapenem by hydrogenation with Raney Nickel, as an alternative to the known catalytic hydrogenation conducted under hydrogen overpressure in the presence of Palladium, starting from corresponding protected intermediates such as p-nitrobenzylesters and with optional suitable protections of any primary and secondary amino functions structurally present.

  使用Raney镍氢化法，作为已知的在钯存在下在氢气压力下进行的催化氢化的替代方法，从相应的保护中间体（如p-硝基苯乙酸甲酯）出发，并选择性地保护任何结构上存在的一级和二级氨基官能团，以方便获得碳青霉烯。
• Meropenem derivatives and uses thereof
  申请人：Kala Pharmaceuticals, Inc.

  公开号：US11091487B2

  公开（公告）日：2021-08-17

  The present invention provides novel derivative of β-lactam antibiotics, such as meropenem. The inventive compounds include compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. Also provided are particles (e.g., nanoparticles) and pharmaceutical compositions thereof that are mucus penetrating. The inventive particles and pharmaceutical compositions may be useful in delivering an inventive compound to the respiratory tract of a subject. The invention further provides methods of using and kits including the inventive compounds, particles thereof, and/or pharmaceutical compositions thereof for treating and/or preventing a pulmonary disease (e.g., a respiratory tract infection).

  本发明提供了β-内酰胺类抗生素的新型衍生物，如美罗培南。本发明化合物包括式（I）化合物及其药学上可接受的盐、溶液剂、水合物、多晶型、共晶体、同系物、立体异构体、同位素标记衍生物和原药。还提供了具有粘液穿透性的颗粒（如纳米颗粒）及其药物组合物。本发明的颗粒和药物组合物可用于向受试者的呼吸道输送本发明的化合物。本发明进一步提供了包括本发明化合物、其颗粒和/或其药物组合物的使用方法和试剂盒，用于治疗和/或预防肺部疾病（如呼吸道感染）。
• OPTICALLY ANISOTROPIC LAYER, METHOD OF MANUFACTURING THE SAME, LAMINATE, METHOD OF MANUFACTURING THE SAME, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY DEVICE, AND ORGANIC EL DISPLAY DEVICE
  申请人：FUJIFILM CORPORATION

  公开号：US20150079380A1

  公开（公告）日：2015-03-19

  To suppress a phenomenon where an optical axis of the optically anisotropic layer is tilted when the optically anisotropic layer is produced by using a liquid crystalline compound showing smectic phase as a materials showing a higher level of orderliness. An optically anisotropic layer wherein a polymerizable composition, containing one or more polymerizable rod-like liquid crystal compound showing a smectic phase, is fixed in a state of smectic phase, and a direction of maximum refractive index of the optically anisotropic layer is inclined at 10° or smaller to the surface of the optically anisotropic layer, a method for manufacturing the same, a laminate and a method for manufacturing the same, a polarizing plate, a liquid crystal display device, and an organic EL display device.