2-Butylsulfanyl-thioisonicotinamide | 180791-06-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-Butylsulfanyl-thioisonicotinamide
• 英文别名: 4-Pyridinecarbothioamide, 2-(butylthio)-；2-butylsulfanylpyridine-4-carbothioamide
• CAS: 180791-06-4
• 化学式: C₁₀H₁₄N₂S₂
• 分子量: 226.367
• InChiKey: FGRYDANKHNKLDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  96.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯-4-氰基吡啶 在 吡啶 、 硫化氢 、 sodium 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-Butylsulfanyl-thioisonicotinamide
  参考文献：
  名称：

  Potential antifungal agents. Synthesis and activity of 2-alkylthiopyridine-4-carbothioamides

  摘要：

  A series of 2-alkylthiopyridine-4-carbothioamides were synthesized, and their antifungal potency was tested. The chemical structures were proved by IR and H-1-NMR data and by elemental analysis. The MIC and MFC assessment were used for the estimation of potential activity in vitro. The study comprising 21 clinical isolates of fungi showed that compounds 5h and 5j exhibited fair inhibitory activity against some yeasts and dermatophytes. Selective fungistatic activity against dermatophytes (MIC = 3.12-25.0 mu g/mL) was found also in compound 5g. None of the above compounds showed inhibitory activity against non-dermatophyte filamentous fungi. Microbiological activity of 2-alkylthiopyridine-4-carbothioamides appears to be mainly related to hydrophobicity of alkyl in position 2.

  DOI：

  10.1016/0223-5234(96)89165-3

文献信息

• Potential antifungal agents. Synthesis and activity of 2-alkylthiopyridine-4-carbothioamides
  作者：V Klimešová、M Otčenášek、K Waisser

  DOI：10.1016/0223-5234(96)89165-3

  日期：1996.1

  A series of 2-alkylthiopyridine-4-carbothioamides were synthesized, and their antifungal potency was tested. The chemical structures were proved by IR and H-1-NMR data and by elemental analysis. The MIC and MFC assessment were used for the estimation of potential activity in vitro. The study comprising 21 clinical isolates of fungi showed that compounds 5h and 5j exhibited fair inhibitory activity against some yeasts and dermatophytes. Selective fungistatic activity against dermatophytes (MIC = 3.12-25.0 mu g/mL) was found also in compound 5g. None of the above compounds showed inhibitory activity against non-dermatophyte filamentous fungi. Microbiological activity of 2-alkylthiopyridine-4-carbothioamides appears to be mainly related to hydrophobicity of alkyl in position 2.