(E)-1,1,1,2,2,3,3,4,4-Nonafluoro-tridec-5-en-7-yne | 320734-03-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: (E)-1,1,1,2,2,3,3,4,4-Nonafluoro-tridec-5-en-7-yne
• 英文别名: (E)-1,1,1,2,2,3,3,4,4-nonafluorotridec-5-en-7-yne
• CAS: 320734-03-0
• 化学式: C₁₃H₁₃F₉
• 分子量: 340.232
• InChiKey: ARNCUDDYGISHST-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  1-庚炔 、 1-iodo-3,3,4,4,5,5,6,6,6-nonafluorohexene 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三乙胺 作用下， 反应 4.0h， 以78%的产率得到(E)-1,1,1,2,2,3,3,4,4-Nonafluoro-tridec-5-en-7-yne
  参考文献：
  名称：

  A Facile Synthesis of Perfluoroalkyl Vinyl Iodides and Their Palladium-Mediated Cross-Coupling Reactions¹

  摘要：

  Catalytic amounts of zinc, as low as 10 mol %, in the presence of trifluoroacetic acid (TFA) initiate the radical addition of perfluoroalkyl iodides to terminal alkynes with high regio- and stereoselectivities. Palladium-mediated cross-coupling of these (E)-perfluoroalkyl vinyl iodides allows for a. facile synthesis of potentially useful fluoroorganic intermediates.

  DOI：

  10.1021/jo001318c

文献信息

• A Facile Synthesis of Perfluoroalkyl Vinyl Iodides and Their Palladium-Mediated Cross-Coupling Reactions¹
  作者：Michael P. Jennings、Elizabeth A. Cork、P. Veeraraghavan Ramachandran

  DOI：10.1021/jo001318c

  日期：2000.12.1

  Catalytic amounts of zinc, as low as 10 mol %, in the presence of trifluoroacetic acid (TFA) initiate the radical addition of perfluoroalkyl iodides to terminal alkynes with high regio- and stereoselectivities. Palladium-mediated cross-coupling of these (E)-perfluoroalkyl vinyl iodides allows for a. facile synthesis of potentially useful fluoroorganic intermediates.