6,8-Dibromo-7-methyl-imidazo[1,2-a]pyridine | 178488-34-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 6,8-Dibromo-7-methyl-imidazo[1,2-a]pyridine
• 英文别名: 6,8-Dibromo-7-methylimidazo[1,2-a]pyridine
• CAS: 178488-34-1
• 化学式: C₈H₆Br₂N₂
• 分子量: 289.957
• InChiKey: PQAFKVLZXPWHRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  17.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6,8-Dibromo-7-methyl-imidazo[1,2-a]pyridine 在 吡啶 、 氯化亚砜 、 sodium acetate 、 溶剂黄146 作用下， 以 乙腈 为溶剂， 反应 2.0h， 生成 3-Benzylsulfanylmethyl-6,8-dibromo-7-methyl-imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Synthesis of Acyclo-C-nucleosides in the Imidazo[1,2-a]pyridine and Pyrimidine Series as Antiviral Agents

  摘要：

  The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.

  DOI：

  10.1021/jm9507901
• 作为产物：
  描述：

  2-氨基-3,5-二溴-4-甲基吡啶 、 溴乙醛 以 乙醇 为溶剂， 以70%的产率得到6,8-Dibromo-7-methyl-imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Synthesis of Acyclo-C-nucleosides in the Imidazo[1,2-a]pyridine and Pyrimidine Series as Antiviral Agents

  摘要：

  The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.

  DOI：

  10.1021/jm9507901

文献信息

• Synthesis of Acyclo-<i>C</i>-nucleosides in the Imidazo[1,2-<i>a</i>]pyridine and Pyrimidine Series as Antiviral Agents
  作者：Alain Gueiffier、Mohammed Lhassani、Ahmed Elhakmaoui、Robert Snoeck、Graciela Andrei、Olivier Chavignon、Jean-Claude Teulade、Abdelali Kerbal、El Mokhtar Essassi、Jean-Claude Debouzy、Myriam Witvrouw、Yves Blache、Jan Balzarini、Erik De Clercq、Jean-Pierre Chapat

  DOI：10.1021/jm9507901

  日期：1996.1.1

  The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.