1-(2-Piperidinylethyl)-2-(3-phenoxyphenyl)benzimidazole | 653573-64-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(2-Piperidinylethyl)-2-(3-phenoxyphenyl)benzimidazole
• 英文别名: 3-(2-piperidin-1-ylethyl)-2-(3-phenoxyphenyl)benzimidazole；1H-Benzimidazole, 2-(3-phenoxyphenyl)-1-[2-(1-piperidinyl)ethyl]-；2-(3-phenoxyphenyl)-1-(2-piperidin-1-ylethyl)benzimidazole
• CAS: 653573-64-9
• 化学式: C₂₆H₂₇N₃O
• 分子量: 397.52
• InChiKey: LVFKLEZAZQIVHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  30.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Aryl substituted benzimidazoles and their use as sodium channel blockers
  申请人：——

  公开号：US20040132777A1

  公开（公告）日：2004-07-08

  This invention relates aryl substituted benzimidazoles of Formula I: 1 or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein R 1 , R 2 , R 10 and n are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

  本发明涉及式I的芳基取代苯并咪唑化合物：1或其药学上可接受的盐、前药或溶剂化物，其中R1、R2、R10和n在规范中定义。本发明还涉及使用式I的化合物治疗全脑和局部缺血后的神经损伤，治疗或预防神经退行性疾病，如肌萎缩性侧索硬化症（ALS），以及治疗、预防或缓解急性或慢性疼痛，作为抗耳鸣剂，抗癫痫药物和抗躁狂抑郁药物，局部麻醉剂，抗心律失常药物以及治疗或预防糖尿病神经病变。
• ARYL SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS SODIUM CHANNEL BLOCKERS
  申请人：Euro-Celtique S.A.

  公开号：EP1532119A2

  公开（公告）日：2005-05-25
• US7022714B2
  申请人：——

  公开号：US7022714B2

  公开（公告）日：2006-04-04
• [EN] ARYL SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS SODIUM CHANNEL BLOCKERS<br/>[FR] BENZIMIDAZOLES ARYLE SUBSTITUEES ET UTILISATION DE CE COMPOSE COMME BLOQUEURS DE CANAL
  申请人：EURO CELTIQUE SA

  公开号：WO2004011439A2

  公开（公告）日：2004-02-05

  This invention relates aryl substituted benzimidazoles of Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein R1, R2, R10 and n are defined in the specification. The invention is also directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.