N-[3,5-dichloro-4-(3-fluoro-4-hydroxy-5-isopropylphenoxy)benzoyl]glycine | 649725-12-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3,5-dichloro-4-(3-fluoro-4-hydroxy-5-isopropylphenoxy)benzoyl]glycine
• 英文别名: 2-[[3,5-dichloro-4-(3-fluoro-4-hydroxy-5-propan-2-ylphenoxy)benzoyl]amino]acetic acid
• CAS: 649725-12-2
• 化学式: C₁₈H₁₆Cl₂FNO₅
• 分子量: 416.233
• InChiKey: WQYPAVCQNCJFLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  methyl-N-[3,5-dichloro-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)benzoyl]glycine 在 三氟二甲基硫醚络合物 、 水 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以20%的产率得到N-[3,5-dichloro-4-(3-fluoro-4-hydroxy-5-isopropylphenoxy)benzoyl]glycine
  参考文献：
  名称：

  [EN] BENZAMIDE OR PHENYLACETAMIDE DERIVATIVES USEFUL AS THYROID RECEPTOR LIGANDS
  [FR] NOUVEAUX COMPOSES

  摘要：

  公开号：

  WO2004007430A3

文献信息

• Novel compounds
  申请人：Garg Neeraj

  公开号：US20060135614A1

  公开（公告）日：2006-06-22

  This invention relates to novel compounds, which are thyroid receptor ligands, and to methods of preparing such compounds. In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which are dependent upon the expression of a T3 regulated gene, wherein a compound as described herein is administered in a therapeutically effective amount.

  本发明涉及一种新型化合物，它们是甲状腺受体配体，并提供了制备这些化合物的方法。此外，本发明还提供了一种预防、抑制或治疗与代谢功能紊乱相关的疾病或随着T3调节基因表达而产生的疾病或障碍的方法，其中所述的化合物以治疗有效量的方式给予。
• Benzamide derivatives as thyroid receptor ligands
  申请人：Karo Bio AB

  公开号：US07153997B2

  公开（公告）日：2006-12-26

  This invention relates to novel compounds, which are thyroid receptor ligands, and to methods of preparing such compounds. In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which are dependent upon the expression of a T3 regulated gene, wherein a compound as described herein is administered in a therapeutically effective amount.

  本发明涉及新型化合物，它们是甲状腺受体配体，并涉及制备这种化合物的方法。此外，提供了一种方法，用于预防、抑制或治疗与代谢功能障碍或依赖于T3调节基因表达的疾病或疾病，其中以本文所述的化合物以治疗有效量的方式给予。
• BENZAMIDE OR PHENYLACETAMIDE DERIVATIVES USEFUL AS THYROID RECEPTOR LIGANDS
  申请人：KARO BIO AB

  公开号：EP1537073A2

  公开（公告）日：2005-06-08
• US7153997B2
  申请人：——

  公开号：US7153997B2

  公开（公告）日：2006-12-26
• [EN] THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING<br/>[FR] COMPOSÉS THYROMIMÉTIQUES UTILISÉS DANS LE TRAITEMENT D'UNE MALADIE ASSOCIÉE À LA VOIE DE SIGNALISATION SONIC HEDGEHOG
  申请人：KAROBIO AB

  公开号：WO2009080835A1

  公开（公告）日：2009-07-02

  This invention relates to compounds for the treatment of disease induced, caused or dependent on activation of the Sonic hedgehog pathway, wherein the compound is a thyromimetic lacking inner-ring iodines. Preferably the compound is of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt, formula (I), wherein G is a group selected from: formula (II) (III) (IV) (IV) and the remaining groups/substituents are as defined herein.