2-methyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4-(trifluoromethyl)-5,6-dihydropyrido[2,3-d]pyrimidin-7-one | 145733-37-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4-(trifluoromethyl)-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
• CAS: 145733-37-5
• 化学式: C₂₃H₁₈F₃N₇O
• 分子量: 465.4
• InChiKey: UMGWNXVFPXRTJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Condensed pyrimidine derivatives and their use as angiotensine II antagonists
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0539086A2

  公开（公告）日：1993-04-28

  This invention relates to pyrrolo-, pyrido-, azepino-, and azocinopyrimidines of the general formula I useful for treating hypertension or congestive heart failure and for preventing or treating restenosis following angioplasty, to pharmaceutical compositions, and to methods for production thereof.

  本发明涉及通式 I 的吡咯并嘧啶、吡啶并嘧啶、氮杂环庚并嘧啶和氮杂环辛并嘧啶。 用于治疗高血压或充血性心力衰竭以及预防或治疗血管成形术后的再狭窄、药物组合物及其生产方法。
• MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS
  申请人：BARLOW Carrolee

  公开号：US20110046090A1

  公开（公告）日：2011-02-24

  The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on use of a GABA agent or GABA analog, in combination with one or more other neurogenic agents, to stimulate or activate the formation of new nerve cells.
• NEUROGENESIS BY MODULATING ANGIOTENSIN
  申请人：BARLOW Carrolee

  公开号：US20110269717A1

  公开（公告）日：2011-11-03

  The instant invention describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The invention includes compositions and methods based on modulating angiotensin activity to stimulate or activate the formation of new nerve cells.
• US5149699A
  申请人：——

  公开号：US5149699A

  公开（公告）日：1992-09-22
• US5256654A
  申请人：——

  公开号：US5256654A

  公开（公告）日：1993-10-26