2,2’-bis(diphenylphosphino)-1,1’-dicyclopentane | 1186106-98-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2’-bis(diphenylphosphino)-1,1’-dicyclopentane
• 英文别名: 2,2'-Bis(diphenylphosphino)-1,1'-bi(cyclopentane)；[2-(2-diphenylphosphanylcyclopentyl)cyclopentyl]-diphenylphosphane
• CAS: 1186106-98-8
• 化学式: C₃₄H₃₆P₂
• 分子量: 506.607
• InChiKey: UKCDADXCAXXBGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  chloro(1,5-cyclooctadiene)rhodium(I) dimer 、 2,2’-bis(diphenylphosphino)-1,1’-dicyclopentane 以 四氢呋喃 为溶剂， 以100%的产率得到[{Rh(BICP)(μ2-Cl)}2]
  参考文献：
  名称：

  中性双核铑二膦配合物[{Rh（diphosphine）（μ2-X）} 2]的原位合成：系统研究

  摘要：

  作为母机对于许多应用，中性二聚体μ 2的类型的-X-桥接二膦铑络合物[{的Rh（二膦）（μ 2 -X）} 2 ]（X =氯，OH）通常在原位由制备另外二膦配体与所述铑配合物[{的Rh（二烯烃）（μ 2 -X）} 2 ]（二烯烃=环辛二烯（COD）或降冰片二烯（NBD）），或[{的Rh（单烯烃）2（μ 2 -Cl） } 2 ]（单烯烃=环辛烯（coe）或乙烯（C 2 H 4））。研究了二膦2,2'-双（二苯基膦基）-1,1'-联萘（BINAP），5,5'-双（二苯基膦基）-4,4'-bi-1,3的原位程序-苯并二恶唑（SEGPHOS），5,5'-双[二（3,5-二甲苯基）膦基] -4,4'-bi-1,3-苯并二恶唑（DM-SEGPHOS），5,5'-双[di （3,5-二叔丁基-4-甲氧基苯基）膦] -4,4'-bi-1,3-苯并二恶唑（DTBM-SEGPHOS），2,2'-双（二苯基膦基）-1

  DOI：

  10.1002/cplu.201402213

文献信息

• METHOD FOR PRODUCING ALCOHOL COMPOUND
  申请人：Shimizu Hideo

  公开号：US20110201819A1

  公开（公告）日：2011-08-18

  Disclosed is a practical method for efficiently producing an alcohol compound by hydrogenating an aldehyde by using a homogeneous copper catalyst which is an easily-available low-cost metal species. Specifically disclosed is a method for producing an alcohol compound, which is characterized in that a hydrogenation reaction of an aldehyde compound is performed in the presence of a homogeneous copper catalyst and a diphosphine compound.

  本文揭示了一种实用的方法，通过使用易获得的低成本金属种类——均相铜催化剂，通过氢化醛类化合物高效产生醇类化合物。具体揭示了一种产生醇类化合物的方法，其特点在于在均相铜催化剂和二膦化合物存在下进行醛类化合物的氢化反应。
• Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl -piperidin-1-yl)-1-propanol compounds
  申请人：DSM CATALYTICA PHARMACEUTICALS, INC.

  公开号：US20030144521A1

  公开（公告）日：2003-07-31

  The present invention provides a process for the preparation of a nonracemic diastereomer of 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol by hydrogenation of a corresponding nonracemic 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanone using a catalyst system comprising ruthenium, a nonracemic diphosphine ligand, a bidentate amine ligand selected from amino-thioethers and achiral diamines, and a base.

  本发明提供了一种制备非外消旋对映体1-(4-苯氧基苯基)-2-(4-羟基-4-苯基哌啶-1-基)-1-丙醇的方法，通过使用催化剂体系对相应的非外消旋1-(4-苯氧基苯基)-2-(4-羟基-4-苯基哌啶-1-基)-1-丙酮进行加氢反应，所述催化剂体系包括钌、非外消旋二膦配体、从氨基硫醚和非手性二胺中选择的双齿胺配体以及碱。
• Catalyzed process of making C-5-substituted heterocyclic inhibitors of 11beta-hydroxy steroid dehydrogenase type 1
  申请人：Bunel Emilio

  公开号：US20070117985A1

  公开（公告）日：2007-05-24

  The invention provides a process for preparing 11 β-hydroxy steroid dehydrogenase type 1 inhibitors of formula 2 via a catalyzed reaction between a compound of formula 1 and a compound of formula R 2 LG in the presence of base: where R 1 , R 2 , X, Y, and LG are described in the specification. Exemplary catalysts contain palladium and one or more phosphine ligands. The process can be performed in a stereoselective manner to give enantiomerically enriched products.

  本发明提供了一种制备11β-羟基类固醇脱氢酶1型抑制剂2的方法，该方法通过在碱存在下，化合物1和化合物R2LG之间催化反应而得到。其中，R1、R2、X、Y和LG在说明书中有描述。示例催化剂包含钯和一个或多个膦配体。该过程可以立体选择性地进行，以得到对映体富集的产物。
• NOVEL COMPOUND, AND FLAVOR COMPOSITION AND/OR FRAGRANCE COMPOSITION CONTAINING SAME
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20170088503A1

  公开（公告）日：2017-03-30

  The present invention addresses the problem of providing a novel compound capable of imparting a highly appealing floral and verdant scent, and a flavor composition and/or fragrance composition containing the same. This compound is a racemic or optically active compound represented by general formula (1). In formula (1), the solid and dotted double line indicates a double bond or a single bond, the definition of Y is the same as described in the specification, and * represents an asymmetric carbon atom.

  本发明解决了提供一种能够赋予高度吸引人的花香和绿色香味的新化合物以及含有该化合物的味道组合物和/或香料组合物的问题。该化合物是由通式（1）表示的混合或光学活性化合物。在式（1）中，实线和虚线双线表示双键或单键，Y的定义与说明书中描述的相同，*表示不对称碳原子。
• Method for Producing Optically Active Alpha-Ionone
  申请人：Yamamoto Tetsuya

  公开号：US20090216039A1

  公开（公告）日：2009-08-27

  Provided that a method for inexpensively producing optically active α-ionone with a high yield and a high asymmetric yield and with good workability in a short process, and a perfume composition comprising the optically active α-ionone obtained by the aforementioned method. A method for producing optically active α-ionone, comprising allowing α-ionone as a mixture of optical isomers to react with an esterification agent, and hydrolyzing the obtained α-ionone enol ester; a method for producing optically active α-ionone comprising subjecting α-ionone as a mixture of optical isomers to an asymmetric reduction, allowing the obtained optically active α-ionol to react with an esterification agent to give an optically active α-ionol ester, hydrolyzing the obtained optically active α-ionol ester after purification as necessary, and then oxidizing the obtained optically active α-ionol; and a perfume composition comprising thus obtained optically active α-ionone.

  提供一种以低成本高产率和高对映选择性的方法制备光学活性α-离子酮，并在短时间内具有良好的可操作性，以及包括上述方法获得的光学活性α-离子酮的香水组合物。一种制备光学活性α-离子酮的方法，包括将光学异构体混合物α-离子酮与酯化剂反应，并水解所得的α-离子酮烯醇酯；一种制备光学活性α-离子酮的方法，包括将光学异构体混合物α-离子酮进行不对称还原，使得所得的光学活性α-离子醇与酯化剂反应，得到光学活性α-离子醇酯，必要时纯化后水解所得的光学活性α-离子醇酯，然后氧化所得的光学活性α-离子醇；以及包括上述所得光学活性α-离子酮的香水组合物。