2-hydroxy-N-[(4E,8E)-3-hydroxy-9-methyl-1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]hexadecanamide | 88642-46-0

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: 2-hydroxy-N-[(4E,8E)-3-hydroxy-9-methyl-1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]hexadecanamide
• CAS: 88642-46-0
• 化学式: C₄₁H₇₇NO₉
• 分子量: 728.1
• InChiKey: YBSQGNFRWZKFMJ-BOLNYJQLSA-N

物化性质

• 熔点：
  188-190 °C
• 沸点：
  876.5±65.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  51
• 可旋转键数：
  32
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  169
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• Transgenic plants expressing a variable domain of a heavy chain antibody (VHH) that binds to a sphingolipid of a fungus
  申请人：AGROSAVFE N.V.

  公开号：US10858666B2

  公开（公告）日：2020-12-08

  This disclosure relates to a transgenic plant or plant tissue or plant cell comprising at least one polynucleotide encoding a polypeptide comprising a variable domain of a heavy-chain antibody (VHH) specifically binding to a sphingolipid of a fungus. This disclosure further relates to a method for protecting at least part of a plant, plant tissue or plant cell from an infection with a plant pathogen, for inhibiting the growth of a plant pathogen on at least part of a plant, plant tissue or plant cell, or for increasing pathogen resistance of at least part of a plant, plant tissue or plant cell.

  本公开涉及一种转基因植物或植物组织或植物细胞，该转基因植物或植物组织或植物细胞包含至少一种多核苷酸，该多核苷酸编码一种多肽，该多肽包含一个重链抗体（VHH）的可变结构域，特异性地与真菌的鞘脂结合。本公开进一步涉及一种方法，用于保护植物、植物组织或植物细胞的至少一部分免受植物病原体的感染，抑制植物病原体在植物、植物组织或植物细胞的至少一部分上的生长，或提高植物、植物组织或植物细胞的至少一部分对病原体的抗性。
• TRANSGENIC PLANT COMPRISING A POLYNUCLEOTIDE ENCODING A VARIABLE DOMAIN OF HEAVY-CHAIN ANTIBODY
  申请人：AGROSAVFE N.V.

  公开号：US20180179551A1

  公开（公告）日：2018-06-28

  This disclosure relates to a transgenic plant or plant tissue. In particular this disclosure relates to a transgenic plant or plant tissue or plant cell comprising at least one polynucleotide comprising at least one sequence encoding a variable domain of a heavy-chain antibody (VHH) specifically binding to a sphingolipid of a fungus. Advantageously, the expression of the polynucleotide in at least part of the transgenic plant or plant tissue or plant cell (i) protects at least part of the transgenic plant or plant tissue or plant cell from an infection with a plant pathogenic fungus, (ii) inhibits the growth of a plant pathogenic fungus on at least part of the transgenic plant or plant tissue or plant cell, or (iii) increases the resistance of at least part of the transgenic plant or plant tissue or plant cell against a plant pathogenic fungus. This disclosure also relates to a method for protecting at least part of a plant or plant tissue or plant cell from an infection with a plant pathogen, for inhibiting the growth of a plant pathogen on at least part of a plant or plant tissue or plant cell, or for increasing pathogen resistance of at least part of a plant or plant tissue or plant cell, comprising expressing in at least part of the plant or plant tissue or plant cell at least one polynucleotide encoding a VHH specifically binding to a pathogen.