[(E)-2-二甲基氨基-3-羟基十八碳-4-烯基]磷酸二氢酯 | 151729-53-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 中文名称: [(E)-2-二甲基氨基-3-羟基十八碳-4-烯基]磷酸二氢酯
• 英文名称: N,N-Dimethylsphingosine-1-phosphate
• 英文别名: [(E)-2-(dimethylamino)-3-hydroxyoctadec-4-enyl] dihydrogen phosphate
• CAS: 151729-53-2
• 化学式: C₂₀H₄₂NO₅P
• 分子量: 407.5
• InChiKey: PVOWCELDZARJJE-WUKNDPDISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  90.2
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• PHARMACEUTICAL COMPOSITION INCLUDING MIGRATORY FACTOR FOR GUIDING PLURIPOTENT STEM CELLS TO INJURY
  申请人：Clio, Inc.

  公开号：EP2962698A1

  公开（公告）日：2016-01-06

  The purpose of the present invention is to identify a migratory factor that guides pluripotent stem cells (Muse cells) useful in new medical applications to damage, and to provide a pharmaceutical composition that includes the migratory factor for promoting tissue regeneration in regenerative medicine that makes use of Muse cells. In the present invention, a receptor that is specifically expressed in Muse cells rather than non-Muse cells was identified, and it was confirmed that a ligand for this receptor can function as a migratory factor. In the present invention, sphingosine-1-phosphate (S1P) was identified as a migratory factor, and thus, the present invention pertains to a pharmaceutical composition for guiding pluripotent stem cells to damage, the composition including SIP as an active ingredient.

  本发明的目的是鉴定一种可引导多能干细胞（缪斯细胞）在新的医疗应用中发挥作用的迁移因子，并提供一种包含该迁移因子的药物组合物，用于促进再生医学中利用缪斯细胞的组织再生。在本发明中，确定了一种在缪斯细胞而非非缪斯细胞中特异表达的受体，并证实该受体的配体可作为迁移因子发挥作用。在本发明中，鞘氨醇-1-磷酸（S1P）被确定为一种迁移因子，因此，本发明涉及一种用于引导多能干细胞受损的药物组合物，该组合物包括作为活性成分的SIP。
• Pharmaceutical composition including migratory factor for guiding pluripotent stem cells to damage
  申请人：CLIO, INC.

  公开号：US10034889B2

  公开（公告）日：2018-07-31

  The purpose of the present invention is to identify a migratory factor that guides pluripotent stem cells (Muse cells) useful in new medical applications to damage, and to provide a pharmaceutical composition that includes the migratory factor for promoting tissue regeneration in regenerative medicine that makes use of Muse cells. In the present invention, a receptor that is specifically expressed in Muse cells rather than non-Muse cells was identified, and it was confirmed that a ligand for this receptor can function as a migratory factor. In the present invention, sphingosine-1-phosphate (S1P) was identified as a migratory factor, and thus, the present invention pertains to a pharmaceutical composition for guiding pluripotent stem cells to damage, the composition including S1P as an active ingredient.

  本发明的目的是鉴定一种可引导多能干细胞（缪斯细胞）在新的医疗应用中发挥作用的迁移因子，并提供一种包含该迁移因子的药物组合物，用于促进再生医学中利用缪斯细胞的组织再生。在本发明中，确定了一种在缪斯细胞而非非缪斯细胞中特异表达的受体，并证实该受体的配体可作为迁移因子发挥作用。在本发明中，鞘氨醇-1-磷酸（S1P）被确定为一种迁移因子，因此，本发明涉及一种引导多能干细胞受损的药物组合物，该组合物包括作为活性成分的S1P。
• Protection of the female reproductive system from natural and artificial insults
  申请人：——

  公开号：US20030157086A1

  公开（公告）日：2003-08-21

  Described are methods for protecting the female reproductive system against natural and artificial insults by administering to women a composition comprising an agent that antagonizes one or more acid sphingomyelinase (ASMase) gene products. Specifically, methods disclosed herein serve to protect women's germline from damage resulting from cancer therapy regimens including chemotherapy or radiotherapy. In one aspect, the method preserves, enhances, or revives ovarian function in women, by administering to women a composition containing sphingosine-1-phosphate, or an analog thereof. Also disclosed are methods to prevent or ameliorate menopausal syndromes and to improve in vitro fertilization techniques.

  本文介绍了保护女性生殖系统免受自然和人工损伤的方法，即给女性服用一种包含拮抗一种或多种酸性鞘磷脂酶（ASMase）基因产物的制剂的组合物。具体来说，本文公开的方法可保护女性生殖系统免受癌症治疗方案（包括化疗或放疗）的损害。在一个方面，该方法通过向妇女施用含有鞘磷脂-1-磷酸或其类似物的组合物来保护、增强或恢复妇女的卵巢功能。还公开了预防或改善更年期综合症和改进体外受精技术的方法。
• EP0671917A4
  申请人：——

  公开号：EP0671917A4

  公开（公告）日：1997-06-18
• METHOD FOR INHIBITION OF CELL MOTILITY BY SPHINGOSINE-1-PHOSPHATE, ITS DERIVATIVES AND MIMETICS AND METHOD OF SYNTHESIZING SPHINGOSINE-1-PHOSPHATE AND ITS DERIVATIVES
  申请人：The Biomembrane Institute

  公开号：EP0671917A1

  公开（公告）日：1995-09-20