6-(aminomethyl)-N-hydroxynicotinimidamide | 400720-48-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(aminomethyl)-N-hydroxynicotinimidamide
• 英文别名: 3-hydroxyamidino-6-aminomethylpyridine；6-(aminomethyl)-N'-hydroxypyridine-3-carboximidamide
• CAS: 400720-48-1
• 化学式: C₇H₁₀N₄O
• 分子量: 166.183
• InChiKey: YFOWHMGUVCWGLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  97.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-(aminomethyl)-N-hydroxynicotinimidamide 在 盐酸 、 N,N-二异丙基乙胺 作用下， 以 水 、 异丙醇 为溶剂， 反应 87.5h， 生成 6-(((5-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-2-yl)methyl)amino)pyrimidine-4-carbonitrile
  参考文献：
  名称：

  WO2020005888A5

  摘要：

  公开号：

  WO2020005888A5
• 作为产物：
  描述：

  6-(aminomethyl)nicotinonitrile hydrochloride 在 羟胺 作用下， 以 乙醇 、 水 为溶剂， 反应 12.0h， 生成 6-(aminomethyl)-N-hydroxynicotinimidamide
  参考文献：
  名称：

  WO2020005888A5

  摘要：

  公开号：

  WO2020005888A5

文献信息

• Non-covalent inhibitors of urokinase and blood vessel formation
  申请人：Corvas International, Inc.

  公开号：US20020037857A1

  公开（公告）日：2002-03-28

  Novel compounds having activity as non-covalent inhibitors of urokinase and having activity in reducing or inhibiting blood vessel formation are provided. These compounds have Pi a group having an amidino or guanidino moiety or derivative thereof. These compounds are useful in vitro for monitoring plasminogen activator levels and in vivo in treatment of conditions which are ameliorated by inhibition of or decreased activity of urokinase and in treating pathologic conditions wherein blood vessel formation is related to a pathologic condition.

  提供了一种具有作为尿激酶非共价抑制剂活性并在减少或抑制血管形成方面具有活性的新化合物。这些化合物具有Pi基团，其中含有一个酰胺基团或鸟胺基团或其衍生物。这些化合物在体外用于监测纤溶酶原激活剂水平，在体内用于治疗通过抑制尿激酶或降低其活性而得到改善的病症，以及用于治疗血管形成与病理病变相关的病理状况。
• CARDIAC SARCOMERE INHIBITORS
  申请人：Cytokinetics, Inc.

  公开号：US20210276991A1

  公开（公告）日：2021-09-09

  Provided are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , Y 1 , Y 2 , L 1 , and G 1 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
• US6586405B2
  申请人：——

  公开号：US6586405B2

  公开（公告）日：2003-07-01
• [EN] NON-COVALENT INHIBITORS OF UROKINASE AND BLOOD VESSEL FORMATION<br/>[FR] INHIBITEURS NON COVALENTS DE L'UROKINASE ET DE LA FORMATION DE VAISSEAUX SANGUINS
  申请人：CORVAS INT INC

  公开号：WO2002014349A2

  公开（公告）日：2002-02-21

  Novel compounds having activity as non-covalent inhibitors of urokinase and having activity in reducing or inhibiting blood vessel formation are provided. These compounds have P1 a group having an amidino or guanidino moiety or derivative thereof. These compounds are useful in vitro for monitoring plasminogen activator levels and in vivo in treatment of conditions which are ameliorated by inhibition of or decreased activity of urokinase and in treating pathologic conditions wherein blood vessel formation is related to a pathologic condition.
• WO2020005888A5
  申请人：——

  公开号：WO2020005888A5

  公开（公告）日：2022-07-04