(-)-R,R-2,8-dichloro-6,12-dihydro-5,11-methanodibenzo-[b,f ][1,5]diazocine*(-)-O,O′-dibenzoyl-L-tartaric acid | 1478259-27-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (-)-R,R-2,8-dichloro-6,12-dihydro-5,11-methanodibenzo-[b,f ][1,5]diazocine*(-)-O,O′-dibenzoyl-L-tartaric acid
• 英文别名: (2R,3R)-2,3-dibenzoyloxybutanedioic acid;5,13-dichloro-1,9-diazatetracyclo[7.7.1.02,7.010,15]heptadeca-2(7),3,5,10(15),11,13-hexaene
• CAS: 1478259-27-6
• 化学式: C₁₅H₁₂Cl₂N₂*C₁₈H₁₄O₈
• 分子量: 649.484
• InChiKey: QFACTBNBAVVYSU-DTPOWOMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  45
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  134
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  (-)-R,R-2,8-dichloro-6,12-dihydro-5,11-methanodibenzo-[b,f ][1,5]diazocine*(-)-O,O′-dibenzoyl-L-tartaric acid 在 sodium carbonate 作用下， 以 二氯甲烷 、 水 为溶剂， 以97%的产率得到2,8-dichloro-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine
  参考文献：
  名称：

  Application of Crystallization-Induced Asymmetric Transformation to a General, Scalable Method for the Resolution of 2,8-Disubstituted Tröger’s Base Derivatives

  摘要：

  A general method for the gram scale resolution of 2-substituted and 2,8-disubstituted Troger's base (TB) derivatives in 63-91% yield has been achieved through the application of crystallization-induced asymmetric transformation (CIAT). Enantiomeric ratios of the resolved TB derivatives range from 99.1:0.9 to >99.5:0.5. Among the Troger's base compounds resolved are four synthetically valuable bromo and iodo derivatives.

  DOI：

  10.1021/jo401873x
• 作为产物：
  描述：

  (-)-O,O′-dibenzoyl-L-tartaric acid monohydrate 、 2,8-dichloro-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine 以 1,2-二氯乙烷 为溶剂， 反应 120.0h， 以91%的产率得到(-)-R,R-2,8-dichloro-6,12-dihydro-5,11-methanodibenzo-[b,f ][1,5]diazocine*(-)-O,O′-dibenzoyl-L-tartaric acid
  参考文献：
  名称：

  Application of Crystallization-Induced Asymmetric Transformation to a General, Scalable Method for the Resolution of 2,8-Disubstituted Tröger’s Base Derivatives

  摘要：

  A general method for the gram scale resolution of 2-substituted and 2,8-disubstituted Troger's base (TB) derivatives in 63-91% yield has been achieved through the application of crystallization-induced asymmetric transformation (CIAT). Enantiomeric ratios of the resolved TB derivatives range from 99.1:0.9 to >99.5:0.5. Among the Troger's base compounds resolved are four synthetically valuable bromo and iodo derivatives.

  DOI：

  10.1021/jo401873x

文献信息

• Application of Crystallization-Induced Asymmetric Transformation to a General, Scalable Method for the Resolution of 2,8-Disubstituted Tröger’s Base Derivatives
  作者：Donald L. Jameson、Thomas Field、Monica R. Schmidt、Alyson K. DeStefano、Christopher J. Stiteler、Vincent J. Venditto、Brooke Krovic、Christopher M. Hoffman、Matthew T. Ondisco、Matthew E. Belowich

  DOI：10.1021/jo401873x

  日期：2013.11.15

  A general method for the gram scale resolution of 2-substituted and 2,8-disubstituted Troger's base (TB) derivatives in 63-91% yield has been achieved through the application of crystallization-induced asymmetric transformation (CIAT). Enantiomeric ratios of the resolved TB derivatives range from 99.1:0.9 to >99.5:0.5. Among the Troger's base compounds resolved are four synthetically valuable bromo and iodo derivatives.