6-fluoro-2-[4-(pyridin-2-yl)but-3-yn-1-yl]imidazo[1,2-a]pyridine monophosphate | 1687740-45-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 6-fluoro-2-[4-(pyridin-2-yl)but-3-yn-1-yl]imidazo[1,2-a]pyridine monophosphate
• 英文别名: Dipraglurant phosphate；6-fluoro-2-(4-pyridin-2-ylbut-3-ynyl)imidazo[1,2-a]pyridine;phosphoric acid
• CAS: 1687740-45-9
• 化学式: C₁₆H₁₂FN₃*H₃O₄P
• 分子量: 363.285
• InChiKey: ZNJYWIJANUVJSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.92
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  6-氟-2-[4-(吡啶-2-基)-3-丁炔基]咪唑并[1,2-A]吡啶 在 磷酸 作用下， 以 甲醇 为溶剂， 生成 6-fluoro-2-[4-(pyridin-2-yl)but-3-yn-1-yl]imidazo[1,2-a]pyridine monophosphate
  参考文献：
  名称：

  WO2015/44270

  摘要：

  公开号：

文献信息

• MONO-PHOSPHATE SALT OF 6-FLUORO-2-[4-(PYRIDIN-2-YL)BUT-3-YN-1-YL]IMIDAZO[1,2A]PYRIDINE AND POLYMORPHS THEREOF AS NEGATIVE ALLOSTERIC MODULATOR OF MGLU5 RECEPTOR
  申请人：Addex Pharma S.A

  公开号：EP3049413A1

  公开（公告）日：2016-08-03
• [EN] MONO-PHOSPHATE SALT OF 6-FLUORO-2-[4-(PYRIDIN-2-YL)BUT-3-YN-1-YL]IMIDAZO[1,2A]PYRIDINE AND POLYMORPHS THEREOF AS NEGATIVE ALLOSTERIC MODULATOR OF MGLU5 RECEPTOR<br/>[FR] SEL MONO-PHOSPHATE DE LA 6-FLUORO-2-[4-(PYRIDIN-2-YL)BUT-3-YN-1 -YL]IMIDAZO[1,2A]PYRIDINE ET POLYMORPHES ASSOCIÉS UTILISÉS COMME MODULATEUR ALLOSTÉRIQUE NÉGATIF DU RÉCEPTEUR MGLU5
  申请人：ADDEX PHARMACEUTICALS SA

  公开号：WO2015044270A1

  公开（公告）日：2015-04-02

  The present invention relates to crystalline and amorphous forms of 6-fluoro-2-[4-(pyridin-2-yl)but-3-yn-1-yl]imidazo[1,2-a]pyridine mono-phosphate salt and methods of making these solid forms thereof. The invention compounds are modulators of mGlu5 which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGlu5 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGlu5 is involved.
• WO2015/44270
  申请人：——

  公开号：——

  公开（公告）日：——