7-O-[2-[[7-[[3,5-bis[6-[3-[6-[3-hydroxy-2-(hydroxymethyl)-2-methylpropoxy]carbonylhept-6-enoyloxy]-2-[6-[3-hydroxy-2-(hydroxymethyl)-2-methylpropoxy]carbonylhept-6-enoyloxymethyl]-2-methylpropoxy]carbonylhept-6-enoyloxymethyl]phenyl]methoxy]-2-methylidene-7-oxoheptanoyl]oxymethyl]-3-[6-[3-hydroxy-2-(hydroxymethyl)-2-methylpropoxy]carbonylhept-6-enoyloxy]-2-methylpropyl] 1-O-[3-hydroxy-2-(hydroxymethyl)-2-methylpropyl] 2-methylideneheptanedioate | 1452877-30-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 7-O-[2-[[7-[[3,5-bis[6-[3-[6-[3-hydroxy-2-(hydroxymethyl)-2-methylpropoxy]carbonylhept-6-enoyloxy]-2-[6-[3-hydroxy-2-(hydroxymethyl)-2-methylpropoxy]carbonylhept-6-enoyloxymethyl]-2-methylpropoxy]carbonylhept-6-enoyloxymethyl]phenyl]methoxy]-2-methylidene-7-oxoheptanoyl]oxymethyl]-3-[6-[3-hydroxy-2-(hydroxymethyl)-2-methylpropoxy]carbonylhept-6-enoyloxy]-2-methylpropyl] 1-O-[3-hydroxy-2-(hydroxymethyl)-2-methylpropyl] 2-methylideneheptanedioate
• CAS: 1452877-30-3
• 化学式: C₁₂₆H₁₉₂O₄₈
• 分子量: 2474.88
• InChiKey: ZORALFWISQLPOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.2
• 重原子数：
  174
• 可旋转键数：
  120
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  716
• 氢给体数：
  12
• 氢受体数：
  48

反应信息

• 作为产物：
  描述：

  7-O-[2-[[7-[[3,5-bis[6-[2-methyl-3-[6-[(2,2,5-trimethyl-1,3-dioxan-5-yl)methoxycarbonyl]hept-6-enoyloxy]-2-[6-[(2,2,5-trimethyl-1,3-dioxan-5-yl)methoxycarbonyl]hept-6-enoyloxymethyl]propoxy]carbonylhept-6-enoyloxymethyl]phenyl]methoxy]-2-methylidene-7-oxoheptanoyl]oxymethyl]-2-methyl-3-[6-[(2,2,5-trimethyl-1,3-dioxan-5-yl)methoxycarbonyl]hept-6-enoyloxy]propyl] 1-O-[(2,2,5-trimethyl-1,3-dioxan-5-yl)methyl] 2-methylideneheptanedioate 在 甲醇 作用下， 反应 6.0h， 以98%的产率得到7-O-[2-[[7-[[3,5-bis[6-[3-[6-[3-hydroxy-2-(hydroxymethyl)-2-methylpropoxy]carbonylhept-6-enoyloxy]-2-[6-[3-hydroxy-2-(hydroxymethyl)-2-methylpropoxy]carbonylhept-6-enoyloxymethyl]-2-methylpropoxy]carbonylhept-6-enoyloxymethyl]phenyl]methoxy]-2-methylidene-7-oxoheptanoyl]oxymethyl]-3-[6-[3-hydroxy-2-(hydroxymethyl)-2-methylpropoxy]carbonylhept-6-enoyloxy]-2-methylpropyl] 1-O-[3-hydroxy-2-(hydroxymethyl)-2-methylpropyl] 2-methylideneheptanedioate
  参考文献：
  名称：

  通过Grob / Eschenmoser反应进行的C–C键断裂，在树枝状大分子合成中的应用†

  摘要：

  结构多样的碳环的C–C键断裂已应用于树枝状聚合物的多样化合成中。该片段已与去保护或硫代迈克尔反应配对，从而可制备分子量分布窄的第四代树状聚合物。增加方法水已经使用附加的羧酸或低聚醚部分检查了溶解度。另外，手性脯氨醇衍生物的掺入导致树枝状大分子的合成，已显示其以良好的产率和适度的对映选择性催化醛的α-胺化。

  DOI：

  10.1039/c3ob40800k

文献信息

• C–C bond fragmentation by Grob/Eschenmoser reactions, applications in dendrimer synthesis
  作者：Judith Hierold、David W. Lupton

  DOI：10.1039/c3ob40800k

  日期：——

  C–C bond fragmentation of structurally diverse carbocycles has been applied to the divergent synthesis of dendrimers. The fragmentation has been paired to deprotection or thio-Michael reaction, allowing the preparation of a fourth generation dendrimer of narrow molecular weight distribution. Methodologies to increase water solubility have been examined using appended carboxylic acid or oligoether moieties

  结构多样的碳环的C–C键断裂已应用于树枝状聚合物的多样化合成中。该片段已与去保护或硫代迈克尔反应配对，从而可制备分子量分布窄的第四代树状聚合物。增加方法水已经使用附加的羧酸或低聚醚部分检查了溶解度。另外，手性脯氨醇衍生物的掺入导致树枝状大分子的合成，已显示其以良好的产率和适度的对映选择性催化醛的α-胺化。