甲泛影葡胺 | 7241-11-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 甲泛影葡胺
• 中文别名: 甲基葡萄糖胺甲泛影酸盐
• 英文名称: Meglumine metrizoate
• 英文别名: 3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoic acid;(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol
• CAS: 7241-11-4
• 化学式: C19H28I3N3O9
• 分子量: 823.2
• InChiKey: TXKOGNLDVKUFSI-WZTVWXICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.22
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  200
• 氢给体数：
  8
• 氢受体数：
  10

文献信息

• Improved medium for the separation of human blood leucocytes
  申请人：Ferrante, Antonio

  公开号：EP0028842A2

  公开（公告）日：1981-05-20

  This invention relates to a method of separation of the leucocyte populations of human blood, and more particularly to a rapid one-step density separation method of mononuclear leucocytes, polymorphonuclear leucocytes and erythrocytes (red blood cells) using a separating medium consisting of a single aqueous solution of (i) an erythrocyte aggregating or clumping agent and (ii) a compound which is highly soluble in water and gives a solution of relatively high density and relatively low viscosity and osmolarity.

  本发明涉及一种分离人体血液中白细胞群的方法，更具体地说，涉及一种单核白细胞、多形核白细胞和红细胞（红血球）的一步快速密度分离法，使用的分离介质包括（i）一种红细胞聚集剂或凝集剂和（ii）一种化合物的单一水溶液，该化合物极易溶于水，可产生密度相对较高、粘度和渗透压相对较低的溶液。
• Contrast media
  申请人：NYCOMED IMAGING AS

  公开号：EP0414288A1

  公开（公告）日：1991-02-27

  There is provided a contrast medium comprising a physiologically tolerable paramagnetic metal species containing substance together with a water soluble iodinated X-ray contrast agent.

  本文提供了一种造影剂，它由一种生理上可耐受的顺磁性金属物质和一种水溶性碘化 X 射线造影剂组成。
• USE OF CARDIOTROPHIN-1 FOR THE TREATMENT OF KIDNEY DISEASES
  申请人：Digna Biotech, S.L.

  公开号：EP2742948A1

  公开（公告）日：2014-06-18

  The present invention relates to the use of cardiotrophin-1 (CT-1) for the prevention and/or treatment of acute renal injury, specially of acute kidney injury induced by nephrotoxic agents, such as contrast agents, antibiotics, immunosuppressive agents or antineoplastic agents. The invention is also related to compositions comprising said nephrotoxic agents and cardiotrophin-1.

  本发明涉及使用心肌营养素-1（CT-1）预防和/或治疗急性肾损伤，特别是由肾毒性制剂（如造影剂、抗生素、免疫抑制剂或抗肿瘤制剂）诱发的急性肾损伤。本发明还涉及由上述肾毒性制剂和心肌营养素-1 组成的组合物。
• Combinatorial analysis and repair
  申请人：Pedersen Henrik

  公开号：US10722562B2

  公开（公告）日：2020-07-28

  A method for the repair of a unit, by specific diagnosis of the undesired state, and its appropriate repair, using said specific diagnosis as a means to repair in an appropriate way said unit. The diagnosis and repair processes may involve chemical, physical, or mechanical means. The units being diagnosed and repaired include live matter (e.g. human beings, animals, plants) as well as non-live matter (e.g. buildings, electronic equipment, polymer materials).

  通过对不希望出现的状态进行特定诊断，并利用所述特定诊断作为以适当方式修复所述装置的手段，对装置进行适当修复的方法。诊断和修复过程可能涉及化学、物理或机械手段。被诊断和修复的单元包括活体（如人类、动物、植物）和非活体（如建筑物、电子设备、高分子材料）。
• Advanced drug development and manufacturing
  申请人：ICAGEN, LLC

  公开号：US10877035B2

  公开（公告）日：2020-12-29

  X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical. For estimating the binding selectivities of a chemical versus chemical analogs, for measuring post translational modification of proteins, and for drug manufacturing.

  X 射线荧光 (XRF) 光谱法已被用于检测化学物质与受体之间的结合事件和测量结合选择性。XRF 还可用于估算化学品的治疗指数。XRF 还可用于估算化学品的治疗指数、估算化学品与化学类似物的结合选择性、测量蛋白质的翻译后修饰以及药物生产。