CY-190602 | 1268704-33-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: CY-190602
• 英文别名: 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]-N-hydroxybutanamide
• CAS: 1268704-33-1
• 化学式: C₁₆H₂₂Cl₂N₄O₂
• 分子量: 373.3
• InChiKey: IORFPLLDGBMLAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  70.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Boronic derivatives of hydroxamates as anticancer agents
  申请人：Xavier University of Louisiana

  公开号：US11046715B2

  公开（公告）日：2021-06-29

  The present disclosure relates to boronic derivatives of hydroxamate compounds, methods for making the same, methods for use as a monotherapy or in combination with one or more other therapeutic agents, for treatment of proliferative diseases such as cancer. The present disclosure also teaches the utilization of said boronic derivatives of hydroxamates as epigenetic therapy medications with enhanced bioavailability, lower-toxicity, and longer-lasting efficacy.

  本公开涉及羟肟酸酯化合物的硼酸衍生物、其制造方法、作为单一疗法或与一种或多种其他治疗剂联合使用的方法，用于治疗癌症等增殖性疾病。本公开还教导了利用所述羟肟酸硼酸衍生物作为表观遗传治疗药物，具有更高的生物利用度、更低的毒性和更持久的疗效。
• RNAi-Based Method of Drug Screening and Characterization
  申请人：Jiang Hai

  公开号：US20140134635A1

  公开（公告）日：2014-05-15

  The invention is directed to a method of characterizing a mechanism of action of an agent (e.g., a chemotherapeutic agent, a genotoxic agent). The method comprises contacting a plurality of populations of cells with an agent to be assessed, wherein each population of cells have one gene of interest targeted by a small hairpin RNA (shRNA) and wherein said gene of interest regulates cell death and a plurality of genes that regulate cell death are targeted in the plurality of populations of cells. A responsiveness of each population of cells to the agent is determined, thereby obtaining an shRNA signature of the agent, so as to identify one or more genes that mediate a response to the agent, thereby characterizing the mechanism of action of the agent. The invention is also directed an article of manufacture for characterizing a mechanism of action of a chemotherapeutic or genotoxic agent.
• BORONIC DERIVATIVES OF HYDROXAMATES AS ANTICANCER AGENTS
  申请人：Xavier University of Louisiana

  公开号：US20200181175A1

  公开（公告）日：2020-06-11

  The present disclosure relates to boronic derivatives of hydroxamate compounds, methods for making the same, methods for use as a monotherapy or in combination with one or more other therapeutic agents, for treatment of proliferative diseases such as cancer. The present disclosure also teaches the utilization of said boronic derivatives of hydroxamates as epigenetic therapy medications with enhanced bioavailability, lower-toxicity, and longer-lasting efficacy.
• US9683231B2
  申请人：——

  公开号：US9683231B2

  公开（公告）日：2017-06-20