8-Hydroxyhydromorphone | 339525-94-9

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 8-Hydroxyhydromorphone
• 英文别名: (4R,4aR,7aR,12bS)-5,9-dihydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
• CAS: 339525-94-9
• 化学式: C₁₇H₁₉NO₄
• 分子量: 301.34
• InChiKey: HKUBHNBSWVSAAH-IPHHTLHHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  70
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• PROCESS
  申请人：JOHNSON MATTHEY PUBLIC LIMITED COMPANY

  公开号：US20150038715A1

  公开（公告）日：2015-02-05

  The present invention provides a process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than 40° C. in the presence of a hydrogenation catalyst and hydrogen gas, wherein the level of 6α-oxymorphol produced is ≦3.00 area % as determined by HPLC.

  本发明提供了一种制备氧吗啡酸加合物的方法，该方法包括将14-羟基吗啡酮和酸的水溶液氢化，形成氧吗啡酸加合物的溶液，其中氢化在存在氢化催化剂和氢气的情况下在一个或多个大于40℃的温度下进行，其中6α-氧吗啡醇的含量≤3.00%（面积百分比），由HPLC确定。
• Process for the preparation of oxymorphone alkaloid and oxymorphone salts
  申请人：JOHNSON MATTHEY PUBLIC LIMITED COMPANY

  公开号：US20150329553A1

  公开（公告）日：2015-11-19

  The present invention provides a process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than 40° C. in the presence of a hydrogenation catalyst and hydrogen gas, wherein the level of 6α-oxymorphol produced is ≦3.00 area % as determined by HPLC.

  本发明提供一种制备羟吗啡酸加合物的方法，该方法包括将14-羟基吗啡酮和酸的水溶液加氢，形成羟吗啡酸加合物的溶液，其中加氢在存在加氢催化剂和氢气的条件下，在一个或多个大于40℃的温度下进行，其中6α-氧吗啡醇的产量≦3.00%（以HPLC测定）。
• PROCESS FOR THE PREPARATION OF OXYMORPHONE
  申请人：Johnson Matthey Public Limited Company

  公开号：EP3027622B1

  公开（公告）日：2019-04-03
• Process for the Preparation of Oxymorphone Alkaloid and Oxymorphone Salts
  申请人：Johnson Matthey Public Limited Company

  公开号：US20190225622A1

  公开（公告）日：2019-07-25

  The present invention provides a process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than 40° C. in the presence of a hydrogenation catalyst and hydrogen gas, wherein the level of 6α-oxymorphol produced is ≤3.00 area % as determined by HPLC.
• US9120800B2
  申请人：——

  公开号：US9120800B2

  公开（公告）日：2015-09-01