3-乙基-1-苯基-咪唑烷-2,4-二酮 | 55889-17-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 3-乙基-1-苯基-咪唑烷-2,4-二酮
• 英文名称: 3-ethyl-1-phenyl-imidazolidine-2,4-dione
• 英文别名: 3-Aethyl-1-phenyl-imidazolidin-2,4-dion；1-phenyl-3-ethyl hydantoin；3-Ethyl-1-phenyl-hydantoin；3-ethyl-1-phenylimidazolidine-2,4-dione
• CAS: 55889-17-3
• 化学式: C₁₁H₁₂N₂O₂
• 分子量: 204.228
• InChiKey: HPXUCPIEUHUFLS-UHFFFAOYSA-N

物化性质

• 熔点：
  149 °C(Solv: ethyl acetate (141-78-6))
• 沸点：
  301.1±25.0 °C(Predicted)
• 密度：
  1.233±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-乙基-1-苯基-咪唑烷-2,4-二酮 、 alkaline earth salt of/the/ methylsulfuric acid 生成 乙胺 、 N-苯基甘氨酸
  参考文献：
  名称：

  Frerichs; Breustedt, Journal fur praktische Chemie (Leipzig 1954), 1902, vol. <2>66, p. 259

  摘要：

  DOI：
• 作为产物：
  描述：

  5-Brom-3-aethyl-1-phenyl-6-methyl-uracil 在 甲胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 以23%的产率得到3-乙基-1-苯基-咪唑烷-2,4-二酮
  参考文献：
  名称：

  Hirota, Kosaku; Banno, Kazuo; Yamada, Yoshihiro, Journal of the Chemical Society. Perkin transactions I, 1985, p. 1137 - 1142

  摘要：

  DOI：

文献信息

• Insecticidal phenyl hydantoin compounds
  申请人：Buffalo Color Corp.

  公开号：US04464387A1

  公开（公告）日：1984-08-07

  Novel phenyl hydantoin compounds are disclosed of the structure: ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen, amino, nitro, halogen, hydroxy, substituted and unsubstituted lower alkyl, cycloalkyl, phenyl and lower alkenyl; and R.sub.3 is substituted and unsubstituted lower alkyl, lower alkenyl and cycloalkyl; as well as pesticidal methods employing said novel compounds; and pesticidal compositions containing said novel compounds.

  新型苯基异恶唑酮化合物的结构已被披露：##STR1## 其中 R.sub.1 和 R.sub.2 独立地是氢、氨基、硝基、卤素、羟基、取代和未取代的较低烷基、环烷基、苯基和较低烯基；而 R.sub.3 是取代和未取代的较低烷基、较低烯基和环烷基；以及利用所述新型化合物的杀虫方法；和含有所述新型化合物的杀虫组合物。
• [EN] SUBSTITUTED QUINOLINES AND THEIR USE AS MEDICAMENTS<br/>[FR] QUINOLÉINES SUBSTITUÉES ET LEUR UTILISATION COMME MÉDICAMENTS
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2013014060A1

  公开（公告）日：2013-01-31

  The invention relates to new substituted quinolines of formula (1) wherein R1 is a linear or branched C1-6-alkyl, wherein R1 may optionally be substituted by R3 which is selected from the group consisting of a three-, four-, five-, six- or seven-membered cycloalkl; a five-, six- or seven-membered, saturated heterocycle comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; and a five- or six-membered heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; wherein R3 may optionally be substituted further substituted as defined in claim 1 and wherein R2 is selected from the group consisting of halogen, phenyl, a five- or six-membered monocyclic heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; a bicyclic, nine-, ten- or eleven-membered, either aromatic or non-aromatic, but not fully saturated heterocycle comprising one, two, three or four heteroatoms each independently selected from the group consisting of N, S and O; wherein R2 may optionally be further substituted as defined in claim 1, and their use in the preparation of medicaments for the treatment of disease such as asthma, COPD, allergic rhinitis, allergic dermatitis and rheumatoid arthritis.

  该发明涉及公式（1）中的新取代喹啉，其中R1是直链或支链的C1-6-烷基，其中R1可以选择性地被R3取代，R3选自以下组：三、四、五、六或七元环烷基；含有一个、两个或三个异原子（分别独立地选自N、S和O）的五、六或七元饱和杂环；含有一个、两个或三个异原子（分别独立地选自N、S和O）的五元或六元杂芳基；其中R3可以选择性地进一步取代，如权利要求书中所定义，R2选自以下组：卤素、苯基、含有一个、两个或三个异原子（分别独立地选自N、S和O）的五元或六元单环杂芳基；含有一个、两个、三或四个异原子（分别独立地选自N、S和O）的九、十或十一元双环芳香或非芳香但不完全饱和杂环；其中R2可以选择性地进一步取代，如权利要求书中所定义，并且它们在制备用于治疗哮喘、慢性阻塞性肺病、过敏性鼻炎、过敏性皮炎和类风湿性关节炎等疾病的药物中的用途。
• [EN] ANTI-BACTERIAL COMPOUNDS BASED ON AMINO-GOLD PHOSPHINE COMPLEXES<br/>[FR] COMPOSÉS ANTIBACTÉRIENS À BASE DE COMPLEXES AMINO PHOSPHINE-OR
  申请人：AUSPHERIX LTD

  公开号：WO2017093545A1

  公开（公告）日：2017-06-08

  A compound of formula (I) for use in the prevention or treatment of a bacterial infection wherein: PX is selected from the group consisting of (P1), (P2) and (P3).

  一种用于预防或治疗细菌感染的化合物，其化学式为（I），其中：PX选自（P1）、（P2）和（P3）组成的群。
• Dye sensitized photographic imaging system
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0269397A2

  公开（公告）日：1988-06-01

  A photographic imaging system is disclosed comprised of a hardenable organic component containing ethylenic unsaturation sites and capable of imagewise modulating mobility as a function of addition at the sites of ethylenic unsaturation, coinitiators for ethylenic addition and, optionally, an imaging dye or a precursor thereof. The coinitiators include an azinium salt activator and a photosensitizer which is a dye exhibiting a reduction potential which in relation to that of said ionized azinium salt activator is at most 0.1 volt more posi­tive, with the further proviso that, when the photo­sensitizer is a keto dye having its principal absorp­tion peak at a wavelength shorter than 550 nm, it exhibits when excited by imaging radiation an inter­system crossing efficiency to a triplet state of less than 10 percent.

  本发明公开了一种照相成像系统，该系统由含有乙烯不饱和位点的可硬化有机成分、乙烯不饱和位点的加成函数、用于乙烯加成的辅助引发剂以及可选的成像染料或其前体组成。 辅助引发剂包括唑盐活化剂和光敏剂，光敏剂是一种染料，其还原电位与所述电离唑盐活化剂的还原电位相比至多正0.1伏，但进一步的条件是，当光敏剂是一种酮染料时，其主吸收峰的波长短于550纳米，在成像辐射的激发下，其到三重态的系统间交叉效率小于10%。
• Enhanced imaging composition containing an azinium activator
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0269398A2

  公开（公告）日：1988-06-01

  An imaging composition is disclosed com­prised of an organic component containing ethylenic unsaturation sites and capable of selective hardening by addition at the sites of ethylenic unsaturation, an azinium salt activator, a photosensitizer having a reduction potential which in relation to the reduc­tion potential of the azinium salt activator is at most 0.1 volt more positive, and an image enhancing amount of benzene substituted with an electron dona­ting amino group and one or more groups capable of imparting a net Hammett sigma value electron with­drawing characteristic of at least +0.20 volt to said benzene ring.

  本发明公开了一种成像组合物，该组合物由含有乙烯不饱和位点并能通过在乙烯不饱和位点上的加成而选择性硬化的有机组分、唑盐活化剂、具有相对于唑盐活化剂的还原电位至多正 0.1 伏的还原电位的光敏剂、以及被供电子氨基和一个或多个能赋予净哈密特西格玛值电子撤回特性至少+0.20 伏的净哈密特西格玛值电子撤回特性的基团取代的苯的图像增强量组成。1伏特的光敏剂，以及用一个电子供体氨基和一个或多个能赋予所述苯环至少+0.20伏特的净哈密特西格玛值电子撤回特性的基团取代的苯的图像增强量。