4-[(E)-2-(4-chlorophenyl)ethenyl]-N-phenyl-1,3-thiazol-2-amine | 1410247-64-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(E)-2-(4-chlorophenyl)ethenyl]-N-phenyl-1,3-thiazol-2-amine
• CAS: 1410247-64-1
• 化学式: C₁₇H₁₃ClN₂S
• 分子量: 312.823
• InChiKey: AXVYFPGOIJHSPE-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (3E)-4-(4-chlorophenyl)-3-buten-2-one 以 乙醇 、 二氯甲烷 为溶剂， 生成 4-[(E)-2-(4-chlorophenyl)ethenyl]-N-phenyl-1,3-thiazol-2-amine
  参考文献：
  名称：

  HTIB-Mediated One-Pot Synthesis of Some 2-Substituted 4-Styrylthiazoles from (E)-4-Arylbut-3-en-2-ones

  摘要：

  The reaction of (E)-4-arylbut-3-en-2-ones with [(hydroxy(tosyloxy)iodo]benzene (HTIB) followed by treatment with thioureas, thioamide, and thiobenzamide has offered a one-pot synthesis of 2-substituted 4-styrylthiazoles.Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.

  DOI：

  10.1080/00397911.2011.604815

文献信息

• HTIB-Mediated One-Pot Synthesis of Some 2-Substituted 4-Styrylthiazoles from (<i>E</i>)-4-Arylbut-3-en-2-ones
  作者：Om Prakash、Nitya Sharma、Pooja Ranjan

  DOI：10.1080/00397911.2011.604815

  日期：2013.1.1

  The reaction of (E)-4-arylbut-3-en-2-ones with [(hydroxy(tosyloxy)iodo]benzene (HTIB) followed by treatment with thioureas, thioamide, and thiobenzamide has offered a one-pot synthesis of 2-substituted 4-styrylthiazoles.Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.