N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-methoxybenzamide | 1311424-23-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-methoxybenzamide
• CAS: 1311424-23-3
• 化学式: C₁₉H₂₀ClF₃N₂O₃
• 分子量: 416.828
• InChiKey: DNSWCGADOLIWLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  50.8
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N,N-二甲基乙醇胺 、 N-[4-chloro-3-(trifluoromethyl)phenyl]-2-hydroxy-6-methoxybenzamide 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 生成 N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-methoxybenzamide
  参考文献：
  名称：

  WO2020163731A5

  摘要：

  公开号：

  WO2020163731A5

文献信息

• HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US20220127232A1

  公开（公告）日：2022-04-28

  Compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.
• [EN] HISTONE ACETYLTRANSFERASE MODULATORS AND COMPOSITIONS AND USES THEREOF<br/>[FR] MODULATEURS D'HISTONE ACÉTYLTRANSFÉRASE ET COMPOSITIONS ET UTILISATIONS ASSOCIÉES
  申请人：UNIV COLUMBIA

  公开号：WO2020163731A1

  公开（公告）日：2020-08-13

  Compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.
• WO2020163731A5
  申请人：——

  公开号：WO2020163731A5

  公开（公告）日：2023-02-15