2-(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetamide | 502632-12-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 2-(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetamide
• 英文别名: 2-(7-methoxy-2-oxochromen-4-yl)acetamide
• CAS: 502632-12-4
• 化学式: C₁₂H₁₁NO₄
• 分子量: 233.22
• InChiKey: WFNLTEHMLIXHCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  78.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof
  申请人：Sekiguchi Yoshinori

  公开号：US20050197350A1

  公开（公告）日：2005-09-08

  The present invention relates to novel compounds of the Formula (I): which act as MCH receptor antagonists. These compositions are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

  本发明涉及一种新的化合物，其化学式为(I)，该化合物作为MCH受体拮抗剂。这些组合物在制药组合物中的应用包括预防或治疗改善记忆功能、睡眠和觉醒、焦虑、抑郁、情绪障碍、癫痫、肥胖症、糖尿病、食欲和进食障碍、心血管疾病、高血压、血脂异常、心肌梗死、暴食症包括贪食症、厌食症、精神障碍包括躁郁症、精神分裂症、谵妄、痴呆、压力、认知障碍、注意力缺陷障碍、物质滥用障碍和运动障碍包括帕金森病、癫痫和成瘾等。
• Pyridine Derivatives and Their Use as Medicaments for Treating Diseases Related to Mch Receptor
  申请人：Sekiguchi Yoshinori

  公开号：US20080090863A1

  公开（公告）日：2008-04-17

  The present invention encompasses novel substituted pyridine compounds of Formula (I): which act as MCH receptor antagonists. These compositions and pharmaceutical compositions thereof are useful in the prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

  本发明涵盖了式（I）的新型取代吡啶化合物，其作为MCH受体拮抗剂。这些组合物及其制药组合物在预防或治疗改善记忆功能、睡眠和觉醒、焦虑、抑郁、情绪障碍、癫痫、肥胖症、糖尿病、食欲和饮食障碍、心血管疾病、高血压、血脂异常、心肌梗死、暴食障碍，包括贪食症、厌食症、精神障碍，包括躁郁症、精神分裂症、谵妄、痴呆、压力、认知障碍、注意力缺陷障碍、物质滥用障碍和运动障碍，包括帕金森病、癫痫和成瘾方面具有用处。
• Combinatorial protease substrate libraries
  申请人：IRM, LLC

  公开号：US20030059847A1

  公开（公告）日：2003-03-27

  Non-peptide protease substrate libraries and high purity protease substrate libraries are constructed, e.g., using fluorogenic compounds. The libraries are useful in obtaining substrate profiles for a variety of proteases, such as methods for determining both prime and non-prime protease recognition sequences.

  非肽蛋白酶底物库和高纯度蛋白酶底物库的构建，例如使用含氟化合物。这些文库可用于获得各种蛋白酶的底物图谱，如确定蛋白酶识别序列的质点和非质点的方法。
• Hepsin substrates and prodrugs
  申请人：IRM, LLC

  公开号：US20040009911A1

  公开（公告）日：2004-01-15

  Substrate specificity profiles are used to determine optimal hepsin substrate sequences, both to the prime side and non-prime side of the hepsin recognition site. The hepsin substrate sequences are used in designing substrates, inhibitors, and prodrugs. For example, prodrugs are provided for use in the treatment of prostate cancer. Hepsin inhibitors based on substrate specificity are also provided.

  底物特异性图谱用于确定最佳的hepsin 底物序列，包括hepsin 识别位点的质子侧和非质子侧。嗜肝素底物序列可用于设计底物、抑制剂和原药。例如，提供了用于治疗前列腺癌的原药。此外，还提供了基于底物特异性的肝素抑制剂。
• Prostasin substrates and inhibitors
  申请人：Harris Jennifer

  公开号：US20050222383A1

  公开（公告）日：2005-10-06

  The invention provides substrate specificity profiles for serine protease prostasin. Optimal prostasin substrate sequences, both to the prime side and non-prime side of the prostasin recognition site, are disclosed herein. The prostasin substrate sequences are used in designing substrates, inhibitors, and prodrugs. Prostasin inhibitors based on substrate specificity are also provided.

  本发明提供了丝氨酸蛋白酶前列素的底物特异性概况。本发明公开了前列腺素识别位点原边和非原边的最佳前列腺素底物序列。前列腺素底物序列可用于设计底物、抑制剂和原药。还提供了基于底物特异性的前列腺素抑制剂。