5-Nitrobenzimidazolium triflate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 5-Nitrobenzimidazolium triflate
• 英文别名: 6-nitro-1H-benzimidazol-3-ium;trifluoromethanesulfonate
• 化学式: C8H6F3N3O5S
• 分子量: 313.21
• InChiKey: IELBPRXADXDMJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.87
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  137
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• PRODUCTION METHOD AND PRODUCTION INTERMEDIATE FOR GUANOSINE-3',5'-BISDIPHOSPHATE
  申请人：TOKYO INSTITUTE OF TECHNOLOGY

  公开号：US20210094980A1

  公开（公告）日：2021-04-01

  The present invention relates to a production method and a production intermediate for guanosine-3′,5′-bisdiphosphate.

  本发明涉及一种鸟苷-3′,5′-双磷酸盐的生产方法和生产中间体。
• [EN] 5'S-LNA NUCLEOTIDES AND OLIGONUCLEOTIDES<br/>[FR] NUCLÉOTIDES ET OLIGONUCLÉOTIDES DE 5'S-LNA
  申请人：HOFFMANN LA ROCHE

  公开号：WO2018019748A1

  公开（公告）日：2018-02-01

  The invention relates to a compound of formula (I) wherein R2 and R4 are joined and together form a group, such a -CH2O-. The compound of formula (I) can be used in the manufacture of 5'S-LNA oligonucleotides as antisense drugs.

  本发明涉及一种式为(I)的化合物，其中R2和R4相连并共同形成一个基团，例如-CH2O-。式(I)的化合物可用于制造5'S-LNA寡核苷酸作为反义药物。
• Linker and support for solid phase synthesis of nucleic acid
  申请人：Nitto Denko Corporation

  公开号：EP2357188A1

  公开（公告）日：2011-08-17

  Provided are a universal linker capable of synthesizing nucleic acid having a phosphate group at the 3' terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. A linker for solid phase synthesis of nucleic acid, containing a compound represented by at least one of the following formulae wherein each symbol is as defined in the specification, is provided.

  本发明提供了一种能够合成在 3'末端具有磷酸基团的核酸的通用连接体、一种携带该连接体的通用支持物以及一种使用该通用支持物的核酸合成方法。 一种用于固相合成核酸的连接剂，含有至少由下式之一代表的化合物 其中各符号如说明书中所定义。
• Linker and Support for Solid Phase Synthesis of Nucleic Acid
  申请人：Nitto Denko Corporation

  公开号：EP2620444A1

  公开（公告）日：2013-07-31

  Provided are a universal linker capable of synthesizing nucleic acid having a hydroxy group at the 3' terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. A linker for solid phase synthesis of nucleic acid, containing a compound represented by the following formula wherein each symbol is as defined in the specification, is provided.

  本发明提供了一种能够合成 3'末端带有羟基的核酸的通用连接剂、一种携带该连接剂的通用支撑剂以及一种使用该通用支撑剂合成核酸的方法。 一种用于固相合成核酸的连接剂，含有下式所代表的化合物 其中各符号如说明书中所定义。
• METHOD FOR PRODUCING RNA
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP3950695A1

  公开（公告）日：2022-02-09

  The present invention provides a method for preparing RNA by a phosphoramidite solid-phase synthesis using an porous inorganic carrier containing a primary amino group, the method being able to bring about an increased purity even in the synthesis of medium-stranded to long-stranded RNA. In the method for producing RNA, an amount of the primary amino group contained in the porous inorganic carrier satisfies the following formula (1): 0.7 ≤ (I × R)/S ≤ 1.8 [wherein, I is an amount of the amino group per unit mass of the porous inorganic carrier (µmol/g), as measured by a 2-nitrobenzenesulfonic acid adsorption method; R is a ratio of the primary amino group in the total amino groups contained in the porous inorganic carrier (amount of primary amino group/amount of total amino groups); and S is a specific surface area (m2/g) of the porous inorganic carrier as measured by a nitrogen adsorption method].

  本发明提供了一种利用含有伯氨基的多孔无机载体通过磷酰胺固相合成制备RNA的方法，该方法即使在合成中链至长链RNA时也能提高纯度。在生产 RNA 的方法中，多孔无机载体中所含伯氨基的量满足下式（1）：0.7 ≤ (i × r)/s ≤ 1.8 [其中，I 为多孔无机载体每单位质量中的氨基量（微摩尔/克），以 2-硝基苯磺酸吸附法测定；R 为多孔无机载体中所含主氨基在总氨基中的比例（主氨基量/总氨基量）；S 为多孔无机载体的比表面积（平方米/克），以氮吸附法测定]。