1,2-dibromo-1,3,4,4-tetrachloro-1,2,3,4-tetrafluoro-butane | 307-20-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: 1,2-dibromo-1,3,4,4-tetrachloro-1,2,3,4-tetrafluoro-butane
• 英文别名: 1,2-Dibrom-1,3,4,4-tetrachlor-1,2,3,4-tetrafluor-butan；1,2-Dibromo-1,3,4,4-tetrachloro-1,2,3,4-tetrafluorobutane；1,2-dibromo-1,3,4,4-tetrachloro-1,2,3,4-tetrafluorobutane
• CAS: 307-20-0
• 化学式: C₄Br₂Cl₄F₄
• 分子量: 425.658
• InChiKey: PNDQFRIYXYCFMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,3,4,4-Trichlorotetrafluoro-1-butene 在 溴 作用下， 生成 1,2-dibromo-1,3,4,4-tetrachloro-1,2,3,4-tetrafluoro-butane
  参考文献：
  名称：

  Invasive fungal sinusitis in the acquired immunodeficiency syndrome

  摘要：

  Invasive fungal sinusitis can present as either an indolent or fulminant process that primarily affects immunocompromised individuals. In this article, the clinical characteristics of four cases of invasive fungal sinusitis in patients with AIDS are analyzed and 22 additional previously reported cases in the literature are reviewed. In addition to HIV infection, other variables common to these cases include facial pain or headache out of proportion to clinical or radiographic findings, CD4 lymphocyte count less than 50 cells/mm(3), absolute neutrophil count less than 1,000 cells/mm(3), subtle radiographic evidence suggesting invasion and an indolent clinical course of the invasive infection. The most common pathogen detected was Aspergillus fumigatus. Maintaining a high index of suspicion, critically assessing these clinical findings, and prudently reviewing CT scans may facilitate early diagnosis and prompt intervention in these patients.

  DOI：

  10.1016/s0030-6665(00)80009-2

文献信息

• 1,2-dibromo-1,3,4,4-tetrachloro-1,2,3,4-tetrafluorobutane
  申请人：DOW CHEMICAL CO

  公开号：US02676193A1

  公开（公告）日：1954-04-20
• Invasive fungal sinusitis in the acquired immunodeficiency syndrome
  作者：Scott M. Hunt、R. Christopher Miyamoto、Rebecca S. Cornelius、Thomas A. Tami

  DOI：10.1016/s0030-6665(00)80009-2

  日期：2000.4

  Invasive fungal sinusitis can present as either an indolent or fulminant process that primarily affects immunocompromised individuals. In this article, the clinical characteristics of four cases of invasive fungal sinusitis in patients with AIDS are analyzed and 22 additional previously reported cases in the literature are reviewed. In addition to HIV infection, other variables common to these cases include facial pain or headache out of proportion to clinical or radiographic findings, CD4 lymphocyte count less than 50 cells/mm(3), absolute neutrophil count less than 1,000 cells/mm(3), subtle radiographic evidence suggesting invasion and an indolent clinical course of the invasive infection. The most common pathogen detected was Aspergillus fumigatus. Maintaining a high index of suspicion, critically assessing these clinical findings, and prudently reviewing CT scans may facilitate early diagnosis and prompt intervention in these patients.