4-(3,4-Dimethyl-phenyl)-6-pyridin-4-yl-pyrimidin-2-ylamine | 914675-03-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-(3,4-Dimethyl-phenyl)-6-pyridin-4-yl-pyrimidin-2-ylamine
• 英文别名: 4-(3,4-Dimethylphenyl)-6-(pyridin-4-yl)pyrimidin-2-amine；4-(3,4-dimethylphenyl)-6-pyridin-4-ylpyrimidin-2-amine
• CAS: 914675-03-9
• 化学式: C₁₇H₁₆N₄
• 分子量: 276.341
• InChiKey: HUFQUTHZYUXDLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  64.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  盐酸胍 、 3-(3,4-dimethylphenyl)-1-(pyridin-4-yl)prop-2-en-1-one 在 sodium isopropylate 作用下， 以 异丙醇 为溶剂， 反应 8.0h， 以68%的产率得到4-(3,4-Dimethyl-phenyl)-6-pyridin-4-yl-pyrimidin-2-ylamine
  参考文献：
  名称：

  Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents

  摘要：

  A series of 2,4,6 trisubstituted pyrimidines and triazines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote model. Nine compounds have shown > 94% inhibition against promastigotes at a concentration of 10 mu g/mL. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.08.009

文献信息

• Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents
  作者：Naresh Sunduru、Anu Agarwal、Sanjay Babu Katiyar、Nishi、Neena Goyal、Suman Gupta、Prem M.S. Chauhan

  DOI：10.1016/j.bmc.2006.08.009

  日期：2006.12

  A series of 2,4,6 trisubstituted pyrimidines and triazines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote model. Nine compounds have shown > 94% inhibition against promastigotes at a concentration of 10 mu g/mL. (c) 2006 Elsevier Ltd. All rights reserved.