3-(2-Butyl-5-chloro-3H-imidazol-4-yl)-2,5-diphenyl-isoxazolidine | 825645-37-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-(2-Butyl-5-chloro-3H-imidazol-4-yl)-2,5-diphenyl-isoxazolidine
• 英文别名: 3-(2-butyl-4-chloro-1H-imidazol-5-yl)-2,5-diphenyl-1,2-oxazolidine
• CAS: 825645-37-2
• 化学式: C₂₂H₂₄ClN₃O
• 分子量: 381.905
• InChiKey: ZGNGEZQDYZKCOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  41.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯乙烯 、 E/Z-C-(2-butyl-4-chloro-1H-imidazolyl)-N-phenyl nitrone 以 xylene 为溶剂， 反应 34.0h， 以76%的产率得到3-(2-Butyl-5-chloro-3H-imidazol-4-yl)-2,5-diphenyl-isoxazolidine
  参考文献：
  名称：

  Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines

  摘要：

  Cycloaddition of C-imidazolyl-N-phenylnitrotles with monosubstituted alkenes afforded 5-imidazolyl substituted isoxazolidines with high regioselectivity. Novel isoxazolidines were screened for their antibacterial activities against S. aureus, E. coli and B. subtilis by using streptomycin as a positive control. They were also tested for their antifungal activities against E moniliforme, A. niger and C. acremonium by using nystatin as a positive control. Isoxazolidines, 4a and 4f exhibited more potent inhibition towards antifungal activity than the other isoxazolidines prepared. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.09.031

文献信息

• Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines
  作者：M.P. Sadashiva、H. Mallesha、N.A. Hitesh、K.S. Rangappa

  DOI：10.1016/j.bmc.2004.09.031

  日期：2004.12

  Cycloaddition of C-imidazolyl-N-phenylnitrotles with monosubstituted alkenes afforded 5-imidazolyl substituted isoxazolidines with high regioselectivity. Novel isoxazolidines were screened for their antibacterial activities against S. aureus, E. coli and B. subtilis by using streptomycin as a positive control. They were also tested for their antifungal activities against E moniliforme, A. niger and C. acremonium by using nystatin as a positive control. Isoxazolidines, 4a and 4f exhibited more potent inhibition towards antifungal activity than the other isoxazolidines prepared. (C) 2004 Elsevier Ltd. All rights reserved.