2-Benzoylamino-octanoic acid tert-butyl ester | 832131-51-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Benzoylamino-octanoic acid tert-butyl ester
• 英文别名: tert-Butyl 2-benzamidooctanoate；tert-butyl 2-benzamidooctanoate
• CAS: 832131-51-8
• 化学式: C₁₉H₂₉NO₃
• 分子量: 319.444
• InChiKey: CYLSZVRZSXQWCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甘氨酸叔丁酯盐酸盐 、 苯甲酰氯 、 1-碘己烷 、 alkaline earth salt of/the/ methylsulfuric acid 以50%的产率得到2-Benzoylamino-octanoic acid tert-butyl ester
  参考文献：
  名称：

  Solid-phase synthetic method for (±)-α-amino acids via phase-transfer catalytic alkylation

  摘要：

  A solid supported glycineimine t-butyl ester was designed and successfully applied to the synthesis of (divided by)-alpha-amino acids. The phase-transfer catalytic alkylation, followed by acidic hydrolysis and benzoylation gave N-benzoyl-alpha-amino acid tert-butyl esters in high yields (up to 92%). (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.11.020

文献信息

• Solid-phase synthetic method for (±)-α-amino acids via phase-transfer catalytic alkylation
  作者：Hyeung-geun Park、Mi-Jeong Kim、Mi-Kyung Park、Hyun-Ju Jung、Jihye Lee、Yeon-Ju Lee、Byeong-Seon Jeong、Jeong-Hee Lee、Mi-Sook Yoo、Jin-Mo Ku、Sang-sup Jew

  DOI：10.1016/j.tetlet.2004.11.020

  日期：2005.1

  A solid supported glycineimine t-butyl ester was designed and successfully applied to the synthesis of (divided by)-alpha-amino acids. The phase-transfer catalytic alkylation, followed by acidic hydrolysis and benzoylation gave N-benzoyl-alpha-amino acid tert-butyl esters in high yields (up to 92%). (C) 2004 Elsevier Ltd. All rights reserved.