H-Asn-Gly-NH2 | 83345-48-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Asn-Gly-NH2
• 英文别名: L-Asparaginylglycinamide；(2S)-2-amino-N-(2-amino-2-oxoethyl)butanediamide
• CAS: 83345-48-6
• 化学式: C₆H₁₂N₄O₃
• 分子量: 188.186
• InChiKey: PAVQPEFYSLQKAF-VKHMYHEASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  141
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Z-Asn-Gly-NH2 在 sodium 、 氯化铵 作用下， 以 氨 为溶剂， 以80%的产率得到H-Asn-Gly-NH2
  参考文献：
  名称：

  肽化学中钠液氨还原过程中副产物的形成

  摘要：

  液态氨中通常过量的钠会还原受保护的模型肽，从而导致产生不希望的副产物。终点的通常公认的蓝色对于完全还原是不必要的。

  DOI：

  10.1039/c39820000639

文献信息

• POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES
  申请人：NEKTAR THERAPEUTICS

  公开号：US20160022828A1

  公开（公告）日：2016-01-28

  The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

  本发明提供了通过共价结合水溶性寡聚体进行化学修饰的肽。本发明的结合物在通过任何一种给药途径进行给药时，表现出与未附着水溶性寡聚体的肽不同的特征。
• Pharmaceutical compositions comprising exendins and agonists thereof
  申请人：AMYLIN PHARMACEUTICALS, INC.

  公开号：EP1629849A2

  公开（公告）日：2006-03-01

  A pharmaceutical composition comprising an exendin or an exendin agonist peptide and a buffer, wherein said composition has a pH of from 3.0 to 8.0, provided that the composition is not suspended in an aqueous buffer at a pH of about 5.6 to 7.4.

  一种药物组合物，包含外显素或外显素激动剂肽和缓冲液，其中所述组合物的 pH 值为 3.0 至 8.0，条件是该组合物未悬浮在 pH 值约为 5.6 至 7.4 的水性缓冲液中。
• Use of exendins and agonists thereof for modulation of triglyceride levels and treatment of dyslipidemia
  申请人：Amylin Pharmaceuticals, Inc.

  公开号：US20030036504A1

  公开（公告）日：2003-02-20

  Methods for modulating the levels of plasma triglyceride and other lipids in a subject which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that lower blood triglyceride and/or other lipid levels.

  调节受试者血浆甘油三酯和其他血脂水平的方法，包括单独或与其他降低血液甘油三酯和/或其他血脂水平的化合物或组合物一起施用有效量的外显素或外显素激动剂。
• Exendins, exendin agonists, and methods for their use
  申请人：——

  公开号：US20030087821A1

  公开（公告）日：2003-05-08

  Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.

  本发明公开了可通过减少食物摄入量来缓解病情或紊乱的治疗方法，包括单独或与其他影响饱腹感的化合物或组合物一起服用有效量的外显素或外显素激动剂。这些方法可用于治疗各种疾病，包括肥胖症、II 型糖尿病、饮食失调和胰岛素抵抗综合征。这些方法还可用于降低血浆葡萄糖水平、降低血浆脂质水平、降低心脏风险、降低食欲和减轻受试者体重。还公开了用于本发明方法的药物组合物。
• Exendin formulations for weight reduction
  申请人：Young A. Andrew

  公开号：US20050043238A1

  公开（公告）日：2005-02-24

  Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.

  本发明公开了可通过减少食物摄入量来缓解病情或紊乱的治疗方法，包括单独或与其他影响饱腹感的化合物或组合物一起服用有效量的外显素或外显素激动剂。这些方法可用于治疗各种疾病，包括肥胖症、II 型糖尿病、饮食失调和胰岛素抵抗综合征。这些方法还可用于降低血浆葡萄糖水平、降低血浆脂质水平、降低心脏风险、降低食欲和减轻受试者体重。还公开了用于本发明方法的药物组合物。