2-Methyl-4-phenylsulfanylbut-3-en-2-ol | 15148-54-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-Methyl-4-phenylsulfanylbut-3-en-2-ol
• 英文别名: 2-methyl-4-phenylsulfanylbut-3-en-2-ol
• CAS: 15148-54-6
• 化学式: C₁₁H₁₄OS
• 分子量: 194.298
• InChiKey: IBULIYJCADKZND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯硫酚 、 2-甲基-3-丁炔-2-醇 在 aluminum oxide 、 potassium fluoride 、 potassium fluoride on basic alumina 作用下， 反应 4.0h， 生成 2-Methyl-4-phenylsulfanylbut-3-en-2-ol 、 2-methyl-3-phenylsulfanylbut-3-en-2-ol
  参考文献：
  名称：

  Synthesis of vinyl sulfides via hydrothiolation of alkynes using Al2O3/KF under solvent-free conditions

  摘要：

  We present here a clean, solvent-free hydrothiolation of alkynes using solid supported catalyst (Al(2)O(3)/KF). This efficient and improved method selectively furnishes the corresponding anti-Markovnikov vinyl sulfides in good to excellent yields. The method is applicable for aliphatic and aromatic thiols and the catalytic system can be re-used up to two times without previous treatment and with comparable activity. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.01.093

文献信息

• Synthesis of vinyl sulfides via hydrothiolation of alkynes using Al2O3/KF under solvent-free conditions
  作者：Márcio S. Silva、Renata G. Lara、Júnior M. Marczewski、Raquel G. Jacob、Eder J. Lenardão、Gelson Perin

  DOI：10.1016/j.tetlet.2008.01.093

  日期：2008.3

  We present here a clean, solvent-free hydrothiolation of alkynes using solid supported catalyst (Al(2)O(3)/KF). This efficient and improved method selectively furnishes the corresponding anti-Markovnikov vinyl sulfides in good to excellent yields. The method is applicable for aliphatic and aromatic thiols and the catalytic system can be re-used up to two times without previous treatment and with comparable activity. (c) 2008 Elsevier Ltd. All rights reserved.