1-(2-Methoxyethoxy)-3-[(prop-2-en-1-yl)oxy]propan-2-ol | 63389-77-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1-(2-Methoxyethoxy)-3-[(prop-2-en-1-yl)oxy]propan-2-ol
• 英文别名: 1-(2-methoxyethoxy)-3-prop-2-enoxypropan-2-ol
• CAS: 63389-77-5
• 化学式: C₉H₁₈O₄
• 分子量: 190.24
• InChiKey: MMJICIIXFVHLHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• POLYSILOXANE MONOMER AND METHOD FOR PRODUCING SAME
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP3611196A1

  公开（公告）日：2020-02-19

  [PROBLEMS TO BE SOLVED] The present invention provides a polysiloxane monomer which gives an ophthalmic device with excellent wettability and a method for preparing the same. [MEANS TO SOLVE THE PROBLEMS] The present invention provides a compound represented by the formula (1) which has a linear polysiloxane structure at the end, a polymerizable group at the other end, and a polyether group or a hydrophilic group as a side chain bound to a linking group which is represented by -(L1)a-CH-L2- in the formula (1) and exists between the polysiloxane structure and the terminal polymerizable group. The compound has excellent compatibility with a hydrophilic monomer, and the surface wettability of hydrogel obtained from the compound as a monomer is improved. The present invention further provides a method for preparing the polysiloxane monomer compound, a polymer having a repeating unit derived from the polymerization at the (meth)acryl group of the polysiloxane monomer compound, and an ophthalmic device containing the polymer.

  [有待解决的问题］ 本发明提供了一种聚硅氧烷单体，该单体可提供润湿性极佳的眼科设备，并提供了制备该设备的方法。 [解决问题的方法］ 本发明提供了一种由式（1）表示的化合物，其一端为线性聚硅氧烷结构，另一端为可聚合基团，聚醚基团或亲水基团作为侧链与连接基团结合，该连接基团在式（1）中由-(L1)a-CH-L2-表示，存在于聚硅氧烷结构和末端可聚合基团之间。该化合物与亲水单体具有良好的相容性，用该化合物作为单体得到的水凝胶的表面润湿性得到改善。本发明进一步提供了一种制备聚硅氧烷单体化合物的方法、一种具有由聚硅氧烷单体化合物的（甲基）丙烯酰基聚合得到的重复单元的聚合物，以及一种含有该聚合物的眼科设备。
• Polysiloxane monomer and method for preparing the same
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US11180614B2

  公开（公告）日：2021-11-23

  A compound represented by the formula (1) is described, which has a linear polysiloxane structure at the end, a polymerizable group at the other end, and a polyether group or a hydrophilic group as a side chain bounded to a linking group which is represented by -(L1)a-CH-L2- in the formula (1) and exists between the polysiloxane structure and the terminal polymerizable group. The compound has excellent compatibility with a hydrophilic monomer, and the surface wettability of hydrogel obtained from the compound as a monomer is improved. Methods are also described for preparing the polysiloxane monomer compound, a polymer having a repeating unit derived from the polymerization at the (meth)acryl group of the polysiloxane monomer compound, and an ophthalmic device containing the polymer.

  描述了一种由式（1）表示的化合物，该化合物一端为线性聚硅氧烷结构，另一端为可聚合基团，聚醚基团或亲水基团作为侧链与连接基团结合，该连接基团在式（1）中由-(L1)a-CH-L2-表示，存在于聚硅氧烷结构和末端可聚合基团之间。该化合物与亲水性单体具有良好的相容性，用该化合物作为单体制备的水凝胶的表面润湿性得到改善。还描述了制备聚硅氧烷单体化合物、具有由聚硅氧烷单体化合物的（甲基）丙烯酰基聚合产生的重复单元的聚合物以及含有该聚合物的眼科设备的方法。
• POLYSILOXANE MONOMER AND METHOD FOR PREPARING THE SAME
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20200148831A1

  公开（公告）日：2020-05-14

  [Problems to be Solved] The present invention provides a polysiloxane monomer which gives an ophthalmic device with excellent wettability and a method for preparing the same. [Means to Solve the Problems] The present invention provides a compound represented by the formula (1) which has a linear polysiloxane structure at the end, a polymerizable group at the other end, and a polyether group or a hydrophilic group as a side chain bounded to a linking group which is represented by -(L 1 ) a -CH-L 2 - in the formula (1) and exists between the polysiloxane structure and the terminal polymerizable group. The compound has excellent compatibility with a hydrophilic monomer, and the surface wettability of hydrogel obtained from the compound as a monomer is improved. The present invention further provides a method for preparing the polysiloxane monomer compound, a polymer having a repeating unit derived from the polymerization at the (meth)acryl group of the polysiloxane monomer compound, and an ophthalmic device containing the polymer.