[2-(Nonan-2-yl)phenoxy]acetic acid | 433734-42-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-(Nonan-2-yl)phenoxy]acetic acid
• 英文别名: 2-(2-nonan-2-ylphenoxy)acetic acid
• CAS: 433734-42-0
• 化学式: C₁₇H₂₆O₃
• 分子量: 278.4
• InChiKey: DPAKPRNCFMBJJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  cyclosporin A 、 、 3,6-二甲基-1,4-二氧杂环己烷-2,5-二酮 、 、 四氢呋喃 反应 16.25h， 以CA-100 polymer was obtained的产率得到[2-(Nonan-2-yl)phenoxy]acetic acid
  参考文献：
  名称：

  PARTICULATE DRUG DELIVERY METHODS

  摘要：

  提供了用于高效制备药物-聚合物（或低聚物）共轭物的方法，该方法可用于制备微粒和纳米粒子，以便在体内传递药物进行治疗应用。本发明还提供了使用本发明的药物-聚合物/低聚物共轭物制备的纳米粒子。药物共轭物是在聚合物或低聚物的聚合过程中形成的，其中药物被用作引发单体聚合的引发剂，这些单体形成聚合物和/或低聚物。更具体地说，药物共轭物是通过在适当的开环聚合催化剂和引发剂（药物）存在下的环开口聚合反应中形成的。该方法特别适用于形成聚合物/低聚物共轭物与含有一个或多个羟基或硫醇基团的药物和其他化学物质。

  公开号：

  US20150314006A1

文献信息

• PARTICULATE DRUG DELIVERY
  申请人：Cheng Jianjun

  公开号：US20080248126A1

  公开（公告）日：2008-10-09

  Methods for efficient preparation of drug-polymer (or oligomer) conjugates which are useful in the preparation of particles, including microparticles and nanoparticles, for delivery of the drug in vivo for therapeutic applications. The invention additionally provides certain drug-polymer and drug-oligomer conjugates which are useful in the preparation of particles for delivery of the drug in vivo. The invention also provides nanoparticles of this invention prepared by nanoprecipitation using drug-polymer/oligomer conjugates of the invention. The drug conjugates are formed during polymerization of the polymer or oligomer in which the drug is employed as an initiator of the polymerization of the monomers which form the polymer and/or oligomer. More specifically, the drug conjugates are formed by ring-opening polymerization of cyclic monomers in the presence of an appropriate ring-opening polymerization catalyst and the initiator (the drug). The method is particularly useful for formation of polymer/oligomer conjugates with drugs and other chemical species containing one or more hydroxyl groups or thiol groups.

  本发明提供了一种有效制备药物-聚合物（或寡聚物）共轭物的方法，该方法可用于制备微粒和纳米粒子，以在体内传递药物进行治疗应用。本发明还提供了某些药物-聚合物和药物-寡聚物共轭物，该共轭物可用于制备体内药物传递的微粒。本发明还提供了通过使用本发明的药物-聚合物/寡聚物共轭物制备的纳米粒子。药物共轭物是在聚合物或寡聚物的聚合过程中形成的，其中药物被用作引发单体聚合形成聚合物和/或寡聚物的引发剂。更具体地说，药物共轭物是通过在适当的开环聚合催化剂和引发剂（药物）的存在下开环聚合环状单体形成的。该方法特别适用于与含有一个或多个羟基或硫醇基团的药物和其他化学物质形成聚合物/寡聚物共轭物。
• PARTICULATE DRUG DELIVERY METHODS
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20150314006A1

  公开（公告）日：2015-11-05

  Methods for efficient preparation of drug-polymer (or oligomer) conjugates useful in the preparation of particles, including microparticles and nanoparticles, for delivery of the drug in vivo for therapeutic applications are provided. The invention also provides nanoparticles prepared by nanoprecipitation using drug-polymer/oligomer conjugates of the invention. The drug conjugates are formed during polymerization of the polymer or oligomer in which the drug is employed as an initiator of the polymerization of the monomers which form the polymer and/or oligomer. More specifically, the drug conjugates are formed by ring-opening polymerization of cyclic monomers in the presence of an appropriate ring-opening polymerization catalyst and the initiator (the drug). The method is particularly useful for formation of polymer/oligomer conjugates with drugs and other chemical species containing one or more hydroxyl groups or thiol groups.

  提供了用于高效制备药物-聚合物（或低聚物）共轭物的方法，该方法可用于制备微粒和纳米粒子，以便在体内传递药物进行治疗应用。本发明还提供了使用本发明的药物-聚合物/低聚物共轭物制备的纳米粒子。药物共轭物是在聚合物或低聚物的聚合过程中形成的，其中药物被用作引发单体聚合的引发剂，这些单体形成聚合物和/或低聚物。更具体地说，药物共轭物是通过在适当的开环聚合催化剂和引发剂（药物）存在下的环开口聚合反应中形成的。该方法特别适用于形成聚合物/低聚物共轭物与含有一个或多个羟基或硫醇基团的药物和其他化学物质。