2-(Methylsulfinyl)ethylmethacrylat | 14794-09-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(Methylsulfinyl)ethylmethacrylat
• 英文别名: 2-(Methanesulfinyl)ethyl 2-methylprop-2-enoate；2-methylsulfinylethyl 2-methylprop-2-enoate
• CAS: 14794-09-3
• 化学式: C₇H₁₂O₃S
• 分子量: 176.236
• InChiKey: LQRGAYMBYFMXNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  62.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(甲基硫代)甲基丙烯酸乙酯 在 双氧水 作用下， 反应 24.0h， 以75%的产率得到2-(Methylsulfinyl)ethylmethacrylat
  参考文献：
  名称：

  Cationic Hyperbranched Polymers with Biocompatible Shells for siRNA Delivery

  摘要：

  阳离子超支化聚合物（HBP）是通过原子转移自由基聚合（ATRP）的乙烯基自缩聚反应制备的，其中包含季铵基团。两种生物相容性壳聚（寡乙二醇）甲基丙烯酸酯（polyOEGMA）和聚（2-甲基亚磺酰基）甲基丙烯酸乙酯（polyDMSO）分别从HBP核心接枝，形成具有低分子量分散性和高生物相容性的核壳结构polyOEGMA-HBP和polyDMSO-HBP。两种结构均表现出低细胞毒性和良好的siRNA复合能力。对基因沉默对Runt相关转录因子2（Runx2）表达的疗效以及成骨细胞培养物中矿化结节形成的长期评估进行了评估。生物相容性核壳结构对于最大限度地减少不良细胞毒性和非特异性基因抑制至关重要。由于壳具有较低的立体位阻，polyDMSO-HBP比polyOEGMA-HBP显示出更高的形成聚复合物的功效。总体而言，两种核壳结构的基因沉默效率与商业试剂Lipofectamine相当，表明基因沉默治疗异位骨化（HO）的长期潜力。

  DOI：

  10.1021/acs.biomac.8b00902

文献信息

• Composition for polymerization, method for producing same, composition for a coating containing composition for polymerization, method for producing composition for a coating using composition for polymerization, and method for producing coating
  申请人：FUJIFILM Corporation

  公开号：US10428168B2

  公开（公告）日：2019-10-01

  A composition for polymerization, which can improve the storage stability in a high-temperature environment when a specific sulfobetaine monomer is stored as powder and can inhibit the discoloration of a cured film when the monomer is made into a cured film, and a method for producing the composition for polymerization; a composition for a coating containing the composition for polymerization, a method for producing the composition for a coating using the composition for polymerization, and a method for producing a coating; the composition for polymerization contains a monomer represented by formula (I) and water, in which the moisture content is equal to or higher than 3% by mass and less than 10% by mass

  一种聚合物化合物，可在特定磺基丙氨酸盐单体作为粉末储存时提高高温环境下的储存稳定性，并且当单体制成固化膜时可以抑制固化膜的变色，以及制备该聚合物化合物的方法；一种含有该聚合物化合物的涂层组合物，使用该聚合物化合物制备涂层组合物的方法以及制备涂层的方法；该聚合物化合物包含式（I）所表示的单体和水，其中水分含量等于或高于3%且低于10%的质量。
• Cationic Hyperbranched Polymers with Biocompatible Shells for siRNA Delivery
  作者：Sipei Li、Maiko Omi、Francis Cartieri、Dominik Konkolewicz、Gordon Mao、Haifeng Gao、Saadyah E. Averick、Yuji Mishina、Krzysztof Matyjaszewski

  DOI：10.1021/acs.biomac.8b00902

  日期：2018.9.10

  Cationic hyperbranched polymers (HBP) were prepared by self-condensing vinyl polymerization of an atom transfer radical polymerization (ATRP) inimer containing a quaternary ammonium group. Two types of biocompatible shells, poly(oligoethylene glycol) methacrylate (polyOEGMA) and poly(2-(methylsulfinyl) ethyl methacrylate) (polyDMSO), were grafted respectively from HBP core to form core–shell structures with low molecular weight dispersity and high biocompatibility, polyOEGMA–HBP and polyDMSO–HBP. Both of the structures showed low cytotoxicity and good siRNA complexing ability. The efficacy of gene silencing against Runt-related transcription factor 2 (Runx2) expression and the long-term assessment of mineralized nodule formation in osteoblast cultures were evaluated. The biocompatible core–shell structures were crucial to minimizing undesired cytotoxicity and nonspecific gene suppression. polyDMSO–HBP showed higher efficacy of forming polyplexes than polyOEGMA–HBP due to shell with lower steric hindrance. Overall, the gene silencing efficiency of both core–shell structures was comparable to commercial agent Lipofectamine, indicating long-term potential for gene silencing to treat heterotopic ossification (HO).

  阳离子超支化聚合物（HBP）是通过原子转移自由基聚合（ATRP）的乙烯基自缩聚反应制备的，其中包含季铵基团。两种生物相容性壳聚（寡乙二醇）甲基丙烯酸酯（polyOEGMA）和聚（2-甲基亚磺酰基）甲基丙烯酸乙酯（polyDMSO）分别从HBP核心接枝，形成具有低分子量分散性和高生物相容性的核壳结构polyOEGMA-HBP和polyDMSO-HBP。两种结构均表现出低细胞毒性和良好的siRNA复合能力。对基因沉默对Runt相关转录因子2（Runx2）表达的疗效以及成骨细胞培养物中矿化结节形成的长期评估进行了评估。生物相容性核壳结构对于最大限度地减少不良细胞毒性和非特异性基因抑制至关重要。由于壳具有较低的立体位阻，polyDMSO-HBP比polyOEGMA-HBP显示出更高的形成聚复合物的功效。总体而言，两种核壳结构的基因沉默效率与商业试剂Lipofectamine相当，表明基因沉默治疗异位骨化（HO）的长期潜力。
• COMPOSITION FOR POLYMERIZATION, METHOD FOR PRODUCING SAME, COATING COMPOSITION CONTAINING SAME, METHOD FOR PRODUCING COATING COMPOSITION CONTAINING SAID COMPOSITIONS, AND METHOD FOR PRODUCING COATING
  申请人：FUJIFILM Corporation

  公开号：EP3260477A1

  公开（公告）日：2017-12-27

  [Problem] Provided is a composition for polymerization that makes it possible to improve the storage stability in high-temperature environments when a specific sulfobetaine monomer is stored as a powder as well as to suppress discoloration when a cured coating film is made, and a method for producing said composition. Also provided are a coating composition containing said composition for polymerization, a method for producing a coating composition in which said compositions are used, and a method for producing a coating. [Solution] A composition for polymerization containing a monomer represented by formula (I) and water, wherein the composition for polymerization has a water content of from 3% by mass to less than 10% by mass. (R represents a hydrogen atom or a methyl group.)

  [问题]提供了一种聚合用组合物，该组合物可以提高特定磺基甜菜碱单体作为粉末储存时在高温环境中的储存稳定性，以及在制作固化涂膜时抑制变色，还提供了生产所述组合物的方法。此外，还提供了含有所述聚合用组合物的涂料组合物、使用所述组合物的涂料组合物的生产方法以及涂料的生产方法。 [解决方案] 一种聚合用组合物，含有由式（I）代表的单体和水，其中聚合用组合物的含水量为 3%（质量）至小于 10%（质量）。 (R 代表氢原子或甲基）。
• CURABLE COMPOSITION, FILM, CURED PRODUCT, AND MEDICAL MEMBER
  申请人：FUJIFILM Corporation

  公开号：EP3699202A1

  公开（公告）日：2020-08-26

  Provided is a curable composition capable of providing a cured product having excellent substrate adhesion and excellent biocompatibility. Also provided are a cured product and a film having excellent substrate adhesion and excellent biocompatibility. Also provided is a medical member including the above cured product. The curable composition contains one or more betaine monomers selected from the group consisting of a compound represented by Formula (1) and a compound represented by Formula (2).

  本发明提供了一种可固化组合物，该组合物能够提供具有优异基底附着力和优异生物相容性的固化产品。还提供了一种固化产品和一种薄膜，其具有优异的基底粘附性和优异的生物相容性。还提供了一种包括上述固化产品的医用部件。固化组合物含有一种或多种甜菜碱单体，这些单体选自由式（1）和式（2）所代表的化合物组成的组。
• Curable composition, film, cured product, and medical member
  申请人：FUJIFILM Corporation

  公开号：US11130831B2

  公开（公告）日：2021-09-28

  A curable composition contains one or more betaine monomers selected from the group consisting of a compound represented by Formula (1) and a compound represented by Formula (2).

  可固化组合物含有一种或多种甜菜碱单体，这些单体选自由式（1）和式（2）所代表的化合物组成的组。