2-[2,2-Diphenyl-2-(tetrahydro-pyran-2-ylsulfanyl)-ethyl]-pyridine | 183470-67-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2,2-Diphenyl-2-(tetrahydro-pyran-2-ylsulfanyl)-ethyl]-pyridine
• 英文别名: 2-{2-[(Oxan-2-yl)sulfanyl]-2,2-diphenylethyl}pyridine；2-[2-(oxan-2-ylsulfanyl)-2,2-diphenylethyl]pyridine
• CAS: 183470-67-9
• 化学式: C₂₄H₂₅NOS
• 分子量: 375.535
• InChiKey: XSHPDZWWQIQFBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  47.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[2,2-Diphenyl-2-(tetrahydro-pyran-2-ylsulfanyl)-ethyl]-pyridine 在 四氯化钛 、 三乙胺 、 2-巯基乙醇 作用下， 以 二氯甲烷 为溶剂， 以93%的产率得到2-(2,2-diphenyl-2-mercaptoethyl)pyridine
  参考文献：
  名称：

  Bulky Thiols and Their Coordination Compounds. An Improvement of the Removal Method of Tetrahydropyranyl Group from Thiols and Its Application for Ligand Syntheses

  摘要：

  The route for the syntheses of alkanthiols having bulky groups at the neighborhood of sulfur atoms was improved, and applied for the preparation of thiol ligands that mimic the cysteine containing metal binding sites in proteins. The new method developed the deprotection of tetrahydropyranyl group from α,α-diphenylalkyl 2-tetrahydropyranyl sulfides.

  DOI：

  10.1246/cl.1996.999
• 作为产物：
  描述：

  、 alkaline earth salt of/the/ methylsulfuric acid 生成 2-[2,2-Diphenyl-2-(tetrahydro-pyran-2-ylsulfanyl)-ethyl]-pyridine
  参考文献：
  名称：

  Bulky Thiols and Their Coordination Compounds. An Improvement of the Removal Method of Tetrahydropyranyl Group from Thiols and Its Application for Ligand Syntheses

  摘要：

  The route for the syntheses of alkanthiols having bulky groups at the neighborhood of sulfur atoms was improved, and applied for the preparation of thiol ligands that mimic the cysteine containing metal binding sites in proteins. The new method developed the deprotection of tetrahydropyranyl group from α,α-diphenylalkyl 2-tetrahydropyranyl sulfides.

  DOI：

  10.1246/cl.1996.999

文献信息

• Bulky Thiols and Their Coordination Compounds. An Improvement of the Removal Method of Tetrahydropyranyl Group from Thiols and Its Application for Ligand Syntheses
  作者：Hideaki Watanabe、Seiji Ogo、Takeshi Yamamura

  DOI：10.1246/cl.1996.999

  日期：1996.11

  The route for the syntheses of alkanthiols having bulky groups at the neighborhood of sulfur atoms was improved, and applied for the preparation of thiol ligands that mimic the cysteine containing metal binding sites in proteins. The new method developed the deprotection of tetrahydropyranyl group from α,α-diphenylalkyl 2-tetrahydropyranyl sulfides.