N-trimethylsilyl-5-methyl-2-pyrrolidinone | 189764-47-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-trimethylsilyl-5-methyl-2-pyrrolidinone
• 英文别名: 5-Methyl-1-(trimethylsilyl)pyrrolidin-2-one；5-methyl-1-trimethylsilylpyrrolidin-2-one
• CAS: 189764-47-4
• 化学式: C₈H₁₇NOSi
• 分子量: 171.315
• InChiKey: RNUCEQXLCSLPFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.83
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-trimethylsilyl-5-methyl-2-pyrrolidinone 在 哌啶 、 bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Synthesis of microcolin analogs using trimethylsilylated lactams

  摘要：

  The synthesis of microcolin analogs is described using an approach that could be of considerable practical interest for structure-activity studies on microcolin and related peptides. This synthetic pathway is more efficient than the methods reported to date, and allows the variation of the Xaa-pyrrolin-2-one unit of these molecules, which has been shown to be crucial for the biological activity. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00336-5
• 作为产物：
  描述：

  三甲基氯硅烷 、 5-甲基-2-吡咯烷酮 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以78%的产率得到N-trimethylsilyl-5-methyl-2-pyrrolidinone
  参考文献：
  名称：

  Synthesis of microcolin analogs using trimethylsilylated lactams

  摘要：

  The synthesis of microcolin analogs is described using an approach that could be of considerable practical interest for structure-activity studies on microcolin and related peptides. This synthetic pathway is more efficient than the methods reported to date, and allows the variation of the Xaa-pyrrolin-2-one unit of these molecules, which has been shown to be crucial for the biological activity. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00336-5

文献信息

• Synthesis of microcolin analogs using trimethylsilylated lactams
  作者：Ralph-Heiko Mattern、Sarath P. Gunasekera、Oliver J. McConnell

  DOI：10.1016/s0040-4039(97)00336-5

  日期：1997.3

  The synthesis of microcolin analogs is described using an approach that could be of considerable practical interest for structure-activity studies on microcolin and related peptides. This synthetic pathway is more efficient than the methods reported to date, and allows the variation of the Xaa-pyrrolin-2-one unit of these molecules, which has been shown to be crucial for the biological activity. (C) 1997 Elsevier Science Ltd.