2-(9H-β-Carbolin-1-yl)-1-piperidin-1-yl-ethanone | 151672-62-7

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: 2-(9H-β-Carbolin-1-yl)-1-piperidin-1-yl-ethanone
• 英文别名: 2-(9H-beta-Carbolin-1-yl)-1-(piperidin-1-yl)ethan-1-one；1-piperidin-1-yl-2-(9H-pyrido[3,4-b]indol-1-yl)ethanone
• CAS: 151672-62-7
• 化学式: C₁₈H₁₉N₃O
• 分子量: 293.368
• InChiKey: AKNAMSUKXQHAFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(9H-β-Carbolin-1-yl)-1-piperidin-1-yl-ethanone 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以55%的产率得到1-(2-Piperidin-1-yl-ethyl)-9H-β-carboline
  参考文献：
  名称：

  Manzamine C congeners with modified azacyclic rings: Synthesis and biological evaluation

  摘要：

  Manzamine C congeners with modified azacyclic rings were synthesized using a DPPA-promoted conjunction of the beta-carboline-1-acetate salt with various amines as a key reaction. A preliminary biological evaluation revealed that these analogues retained similar activities as Manzamine C. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00460-x
• 作为产物：
  描述：

  1-(ethoxycarbonylmethyl)-β-carboline 在 氢氧化钾 、 二苯基磷酸 、 三乙胺 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 生成 2-(9H-β-Carbolin-1-yl)-1-piperidin-1-yl-ethanone
  参考文献：
  名称：

  Manzamine C congeners with modified azacyclic rings: Synthesis and biological evaluation

  摘要：

  Manzamine C congeners with modified azacyclic rings were synthesized using a DPPA-promoted conjunction of the beta-carboline-1-acetate salt with various amines as a key reaction. A preliminary biological evaluation revealed that these analogues retained similar activities as Manzamine C. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00460-x

文献信息

• Manzamine C congeners with modified azacyclic rings: Synthesis and biological evaluation
  作者：Yasuhiro Torisawa、Akihiro Hashimoto、Miwa Okouchi、Takamasa Iimori、Mieko Nagasawa、Tohru Hino、Masako Nakagawa

  DOI：10.1016/0960-894x(96)00460-x

  日期：1996.11

  Manzamine C congeners with modified azacyclic rings were synthesized using a DPPA-promoted conjunction of the beta-carboline-1-acetate salt with various amines as a key reaction. A preliminary biological evaluation revealed that these analogues retained similar activities as Manzamine C. Copyright (C) 1996 Elsevier Science Ltd