2-(2,4-dimethoxyphenyl)-2-ethyl-1,3-dioxolane | 137516-81-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,4-dimethoxyphenyl)-2-ethyl-1,3-dioxolane
• 英文别名: 2-(2,4-Dimethoxyphenyl)-2-ethyl-1,3-dioxolane
• CAS: 137516-81-5
• 化学式: C₁₃H₁₈O₄
• 分子量: 238.284
• InChiKey: VEDCGDKVLMORSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2,4-dimethoxyphenyl)-2-ethyl-1,3-dioxolane 在 水 、 氢气 、 sodiummonodecylphosphate 作用下， 以 乙腈 为溶剂， 生成 2′,4′-二甲氧基苯丙酮 、 乙二醇
  参考文献：
  名称：

  磷酸单烷基酯表面活性剂对二氧戊环酸水解的影响

  摘要：

  The pseudophase ion-exchange (PPIE) model was tested in the presence and absence of buffer for the acid-catalyzed hydrolysis of 2-(p-methoxyphenyl)-1,3-dioxolane (p-MPD) and 2-(2,4-dimethoxyphenyl)-2-ethyl-1,3-dioxolane (2,4-DPED) in the presence of sodium monoalkyl phosphate surfactants. The maximum increase in the observed rate constant was about 10-fold for both substrates. The second-order rate constant for the acid hydrolysis of 2,4-DPED in the micellar phase of the phosphate surfactants (k2m = 14.3 M-1 s-1) is similar to that observed in the bulk aqueous phase (k2,w = 12.7 M-1 s-1). When p-MPD was used as a substrate, a modest 3-fold enhancement in the second-order rate constant is found. The application of the PPIE model requires careful pH measurements, since the surfactant itself is a weak acid.

  DOI：

  10.1021/j100182a080

文献信息

• Effects of monoalkyl phosphate surfactants upon the acid hydrolysis of dioxolanes
  作者：Angelo A. Ruzza、Maria Rosania K. Walter、Faruk Nome、Dino Zanette

  DOI：10.1021/j100182a080

  日期：1992.2

  The pseudophase ion-exchange (PPIE) model was tested in the presence and absence of buffer for the acid-catalyzed hydrolysis of 2-(p-methoxyphenyl)-1,3-dioxolane (p-MPD) and 2-(2,4-dimethoxyphenyl)-2-ethyl-1,3-dioxolane (2,4-DPED) in the presence of sodium monoalkyl phosphate surfactants. The maximum increase in the observed rate constant was about 10-fold for both substrates. The second-order rate constant for the acid hydrolysis of 2,4-DPED in the micellar phase of the phosphate surfactants (k2m = 14.3 M-1 s-1) is similar to that observed in the bulk aqueous phase (k2,w = 12.7 M-1 s-1). When p-MPD was used as a substrate, a modest 3-fold enhancement in the second-order rate constant is found. The application of the PPIE model requires careful pH measurements, since the surfactant itself is a weak acid.