3-氨基-6-甲基-吡嗪-2-羧酸酰胺 | 820250-28-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 3-氨基-6-甲基-吡嗪-2-羧酸酰胺
• 英文名称: 3-amino-6-methyl-pyrazine-2-carboxylic acid amide
• 英文别名: 3-Amino-6-methyl-pyrazin-2-carbonsaeure-amid；3-Amino-6-methyl-pyrazin-2-carbonamid；2-Amino-3-carbamoyl-5-methylpyrazin；3-Amino-6-methylpyrazine-2-carboxamide；3-amino-6-methylpyrazine-2-carboxamide
• CAS: 820250-28-0
• 化学式: C₆H₈N₄O
• 分子量: 152.156
• InChiKey: VDNKYDCPCDFZEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  94.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-氨基-6-甲基-吡嗪-2-羧酸酰胺 在 sodium hydroxide 作用下， 生成 3-氨基-6-甲基吡嗪-2-羧酸甲酯
  参考文献：
  名称：

  Pteridines. XVIII. A Direct Synthesis of 2-Aminopyrazine-3-carboxamides^1,2

  摘要：

  DOI：

  10.1021/ja01519a047
• 作为产物：
  描述：

  5-甲基-1H-吡唑并[3,4-b]吡嗪-3-醇 在 乙醇 、 镍 作用下， 生成 3-氨基-6-甲基-吡嗪-2-羧酸酰胺
  参考文献：
  名称：

  Pteridines. XVI. A Synthesis of 2-Aminopyrazine-3-carboxamides by Reductive Ring Cleavage of 3-Hydroxy-1-pyrazolo [b] pyrazines^1-3

  摘要：

  DOI：

  10.1021/ja01535a045

文献信息

• Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
  申请人：Bellenie Benjamin Richard

  公开号：US10004732B2

  公开（公告）日：2018-06-26

  The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

  本发明提供了抑制 PI 3-kinase gamma 异构体活性的式 (I) 化合物，可用于治疗由 PI 3-kinase gamma 异构体活化介导的疾病。
• Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
  作者：Songnian Lin、Matthew Lombardo、Sunita Malkani、Jeffrey J. Hale、Sander G. Mills、Kevin Chapman、James E. Thompson、Wen Xiao Zhang、Ruixiu Wang、Rose M. Cubbon、Edward A. O’Neill、Silvi Luell、Ester Carballo-Jane、Lihu Yang

  DOI：10.1016/j.bmcl.2009.04.088

  日期：2009.6

  Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas are described as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). These compounds demonstrate potent in vitro activity against the enzyme with IC50 values as low as 15 nM, and suppress expression of TNF alpha in THP-1 cells and in vivo in an acute inflammation model in mice. The synthesis, structure-activity relationship (SAR), and biological evaluation of these compounds are discussed. (C) 2009 Elsevier Ltd. All rights reserved.
• AMINO PYRAZINE DERIVATIVES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
  申请人：BELLENIE Benjamin Richard

  公开号：US20170042889A1

  公开（公告）日：2017-02-16

  The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.
• Pteridines. XVI. A Synthesis of 2-Aminopyrazine-3-carboxamides by Reductive Ring Cleavage of 3-Hydroxy-1-pyrazolo [b] pyrazines^1-3
  作者：E. C. Taylor、J. W. Barton、T. S. Osdene

  DOI：10.1021/ja01535a045

  日期：1958.1
• Pteridines. XVIII. A Direct Synthesis of 2-Aminopyrazine-3-carboxamides^1,2
  作者：O. Vogl、Edward C. Taylor

  DOI：10.1021/ja01519a047

  日期：1959.5