1-(pyren-1-ylmethyl)-1,4,7,10-tetraazacyclododecane | 1536395-47-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: 1-(pyren-1-ylmethyl)-1,4,7,10-tetraazacyclododecane
• 英文别名: 1-(pyren-1-methyl)-1,4,7,10-tetraazacyclododecane；1-(pyren-1-ylmethyl)-1,4,7,10-tetraazacvclododecane；1-(Pyren-1-ylmethyl)-1,4,7,10-tetrazacyclododecane
• CAS: 1536395-47-7
• 化学式: C₂₅H₃₀N₄
• 分子量: 386.54
• InChiKey: DQNMUMXFYVXILG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  39.3
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(pyren-1-ylmethyl)-1,4,7,10-tetraazacyclododecane 、 zinc trifluoromethanesulfonate 以 乙腈 为溶剂， 反应 2.0h， 生成 1-(pyren-1-methyl)-1,4,7,10-tetraazacyclododecane zinc(II) trifluoromethanesulfonate
  参考文献：
  名称：

  [EN] SENSORS FOR DETECTION OF NEGATIVELY CHARGED PHOSPHATE-CONTAINING MEMBRANES AND MEMBRANE COMPONENTS
  [FR] CAPTEURS POUR LA DÉTECTION DE MEMBRANES CONTENANT DU PHOSPHATE CHARGÉES NÉGATIVEMENT ET COMPOSANTS DE MEMBRANE

  摘要：

  该应用涉及一种检测带负电的磷酸盐含量的膜和膜组分的方法，例如细胞膜或人工脂质囊泡，并且其用途包括检测凋亡和细菌感染。

  公开号：

  WO2019068177A1
• 作为产物：
  描述：

  1,4,7-tri-tert-butyl 10-(pyren-1-ylmethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-tricarboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以96%的产率得到1-(pyren-1-ylmethyl)-1,4,7,10-tetraazacyclododecane
  参考文献：
  名称：

  [EN] EXCIMER FORMING COMPOUNDS
  [FR] COMPOSÉS FORMANT DES EXCIMÈRES

  摘要：

  本申请涉及公式I的激聚物化合物：W-V-[Y]n，其中W是激聚物形成的荧光团，V是连接基团，Y是金属离子配位基团，n为1、2或3。具体而言，该申请涉及用于检测近端磷酸化位点的激聚物化合物，包括在蛋白质、多肽、焦磷酸盐和RNA上发现的位点，例如在水溶液、聚丙烯酰胺凝胶印迹膜、固相支持测定和细胞培养样品中。

  公开号：

  WO2015089639A1

文献信息

• Excimer forming compounds
  申请人：THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

  公开号：US10889554B2

  公开（公告）日：2021-01-12

  The present application is directed to excimer forming compounds of Formula I: W—V—[Y]n wherein W is an excimer forming fluorophore, V is a linker moiety, Y is a metal ion coordinating moiety and n is 1, 2 or 3. In particular, the application is directed to excimer forming compounds for the detection of proximally phosphorylated sites including those found on polypeptides, proteins, pyrophosphate and RNA, for example in aqueous solution, polyacrylamide gels blotting membranes, solid-support assays and in cell culture samples.

  本申请涉及式 I 的准分子形成化合物：其中 W 是形成准分子的荧光团，V 是连接基团，Y 是金属离子配位基团，n 是 1、2 或 3。具体而言，本申请涉及用于检测近端磷酸化位点（包括多肽、蛋白质、焦磷酸和 RNA 上的磷酸化位点）的准分子形成化合物，例如在水溶液、聚丙烯酰胺凝胶印迹膜、固体支持检测和细胞培养样品中。
• An Excimer-Based, Turn-On Fluorescent Sensor for the Selective Detection of Diphosphorylated Proteins in Aqueous Solution and Polyacrylamide Gels
  作者：Dziyana Kraskouskaya、Matthew Bancerz、Harjeet S. Soor、Jordan E. Gardiner、Patrick T. Gunning

  DOI：10.1021/ja411492k

  日期：2014.1.29

  Protein phosphorylation is a ubiquitous post-translational modification, which often acts as a switch to proteins' activation and is frequently perturbed in diseases. Although many general phospho-protein detection tools are available, none of them offers information about the relative spatial arrangement of phosphorylated residues. Specifically, proximally phosphorylated residues are hallmarks of certain activated disease-relevant proteins. We herein report the first turn-on fluorescent sensor for the selective detection of proximally phosphorylated protein sites, suitable for application in both aqueous solutions and polyacrylamide gels.
• EXCIMER FORMING COMPOUNDS
  申请人：THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

  公开号：US20160304473A1

  公开（公告）日：2016-10-20

  The present application is directed to excimer forming compounds of Formula I: W—V—[Y] n wherein W is an excimer forming fluorophore, V is a linker moiety, Y is a metal ion coordinating moiety and n is 1, 2 or 3. In particular, the application is directed to excimer forming compounds for the detection of proximally phosphorylated sites including those found on polypeptides, proteins, pyrophosphate and RNA, for example in aqueous solution, polyacrylamide gels blotting membranes, solid-support assays and in cell culture samples.
• SENSORS FOR DETECTION OF NEGATIVELY CHARGED PHOSPHATE-CONTAINING MEMBRANES AND MEMBRANE COMPONENTS
  申请人：THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

  公开号：US20200270218A1

  公开（公告）日：2020-08-27

  This application relates to a method of detecting negatively charged phosphate-containing membranes and membrane components, such as in cell membranes or artificial lipid vesicles, and its use, for example, in detecting apoptosis and bacterial infection.