1-tert-butoxycarbonylamino-2-(4-hydroxybutyl)benzene | 944467-40-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-tert-butoxycarbonylamino-2-(4-hydroxybutyl)benzene
• 英文别名: tert-butyl N-[2-(4-hydroxybutyl)phenyl]carbamate
• CAS: 944467-40-7
• 化学式: C₁₅H₂₃NO₃
• 分子量: 265.353
• InChiKey: UKAXYYDTFINGSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-tert-butoxycarbonylamino-2-(4-hydroxybutyl)benzene 在 吡啶 、 草酰氯 、 二异丁基氢化铝 、 三乙胺 作用下， 以 二氯甲烷 、 二甲基亚砜 、 甲苯 为溶剂， 反应 26.0h， 生成 1-tert-butoxycarbonylamino-2-(6-acetoxy-4-hexenyl)benzene
  参考文献：
  名称：

  Synthesis of 2,6-dimethyl-9-aryl-9-phosphabicyclo[3.3.1]nonanes: their application to asymmetric synthesis of chiral tetrahydroquinolines and relatives

  摘要：

  Synthesis of 2,6-dimethyl-9-aryl-9-phosphabicyclo[3.3.1]nonanes from 1,5-cyclooctadiene and their application to asymmetric cyclization leading to chiral tetrahydroquinolines and relatives through palladium-catalyzed allylic alkylation are described. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.03.078
• 作为产物：
  描述：

  1-tert-butoxycarbonylamino-2-[4-(tetrahydropyran-2-yloxy)butyl]benzene 在 4-甲基苯磺酸吡啶 作用下， 以 乙醇 为溶剂， 反应 16.0h， 以59%的产率得到1-tert-butoxycarbonylamino-2-(4-hydroxybutyl)benzene
  参考文献：
  名称：

  Synthesis of 2,6-dimethyl-9-aryl-9-phosphabicyclo[3.3.1]nonanes: their application to asymmetric synthesis of chiral tetrahydroquinolines and relatives

  摘要：

  Synthesis of 2,6-dimethyl-9-aryl-9-phosphabicyclo[3.3.1]nonanes from 1,5-cyclooctadiene and their application to asymmetric cyclization leading to chiral tetrahydroquinolines and relatives through palladium-catalyzed allylic alkylation are described. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.03.078

文献信息

• NOVEL MAYTANSINOID DERIVATIVES WITH PEPTIDE LINKER AND CONJUGATES THEREOF
  申请人：Widdison Wayne C.

  公开号：US20130029900A1

  公开（公告）日：2013-01-31

  The invention relates to novel cell-binding agent-cytotoxic agent conjugate having a peptide linkers and more specifically to conjugates of formula (I). The invention also provides novel cytotoxic agents of formula (II), linker compounds represented by formula (III), and drug-linker compounds represented by formula (IV). The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.

  本发明涉及具有肽连接物的新型细胞结合剂-细胞毒剂偶联物，更具体地涉及式(I)的偶联物。本发明还提供式(II)的新型细胞毒剂，由式(III)表示的连接物和由式(IV)表示的药物-连接物化合物。本发明还提供使用本发明的化合物或偶联物抑制异常细胞生长或治疗哺乳动物的增殖性疾病的组合物和方法。
• US9289512B2
  申请人：——

  公开号：US9289512B2

  公开（公告）日：2016-03-22
• [EN] NOVEL MAYTANSINOID DERIVATIVES WITH PEPTIDE LINKER AND CONJUGATES THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS DE MAYTANSINOÏDE COMPRENANT UN LIEUR PEPTIDIQUE ET CONJUGUÉS CORRESPONDANTS
  申请人：IMMUNOGEN INC

  公开号：WO2012177837A2

  公开（公告）日：2012-12-27

  The invention relates to novel cell-binding agent-cytotoxic agent conjugate having a peptide linkers and more specifically to conjugates of formula (I). The invention also provides novel cytotoxic agents of formula (II), linker compounds represented by formula (III), and drug-linker compounds represented by formula (IV). The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
• Synthesis of 2,6-dimethyl-9-aryl-9-phosphabicyclo[3.3.1]nonanes: their application to asymmetric synthesis of chiral tetrahydroquinolines and relatives
  作者：Osamu Hara、Tomoaki Koshizawa、Kazuishi Makino、Iyo Kunimune、Atsushi Namiki、Yasumasa Hamada

  DOI：10.1016/j.tet.2007.03.078

  日期：2007.7

  Synthesis of 2,6-dimethyl-9-aryl-9-phosphabicyclo[3.3.1]nonanes from 1,5-cyclooctadiene and their application to asymmetric cyclization leading to chiral tetrahydroquinolines and relatives through palladium-catalyzed allylic alkylation are described. (c) 2007 Elsevier Ltd. All rights reserved.