| 17289-70-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 17289-70-2
• 化学式: C7H6NaO4
• 分子量: 177.11
• InChiKey: FPCQPFCFOQESMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.42
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• An orally administrable drug form comprising a beta-lactam antibiotic and an adjuvant
  申请人：INTERx RESEARCH CORPORATION

  公开号：EP0036534A1

  公开（公告）日：1981-09-30

  A drug form is provided for increasing the oral absorption of β-lactam antibiotics such as the penicillins, cephalosporins and related chemical species by the oral administration of said β-lactam antibiotics in a suitable pharmaceutically accepted excipient to which has been added a hydroxy aryl or hydroxy aralkyl acid or salt, amide or ester thereof. The hydroxyaryl or hydroxyaralkyl acid or salt, amide or ester thereof is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of the β-lactam antibiotic.

  本发明提供了一种药物形式，通过将β-内酰胺类抗生素口服于适当的药学上可接受的赋形剂中，并在赋形剂中加入羟基芳基或羟基芳烷基酸或其盐、酰胺或酯，从而增加β-内酰胺类抗生素如青霉素类、头孢菌素类及相关化学物质的口服吸收。羟基芳基或羟基烷基酸或其盐、酰胺或酯在药物形式中的含量足以有效提高 β-内酰胺类抗生素的口服吸收率。
• An orally administered drug form comprising a polar bioactive agent and an adjuvant
  申请人：INTERx RESEARCH CORPORATION

  公开号：EP0036145A1

  公开（公告）日：1981-09-23

  A drug form is provided for increasing the oral absorption of polar bioactive agents such as xanthines, polyhydroxylic substances, zwitterions, polypeptides and organic anions and related chemical species by the oral administration of said polar bioactive agents in a suitable pharmaceutically accepted excipientto which has been added a hydroxyaromatic, hydroxyaryl or hydroxy aralkyl acid or salt amide or ester thereof. The hydroxy aryl or hydroxy aralkyl acid or salt amide or ester thereof is present in the drug form in quantities suffi- cientto be effective in enhancing the rate of oral absorption of the polar bioactive agents.

  本发明提供了一种药物剂型，用于增加极性生物活性剂（如黄嘌呤、多羟基物质、 齐聚物、多肽和有机阴离子及相关化学物质）的口服吸收，方法是将所述极性生物活性 剂口服在一种适当的药学上可接受的赋形剂中，在赋形剂中添加羟基芳基、羟基芳基或 羟基烷基酸或其酰胺盐或酯。羟基芳基或羟基烷基酸或其酰胺盐或酯在药物形式中的存在量足以有效提高极性生物活性剂的口服吸收率。
• Binders for powder and magnetic recording media using same
  申请人：NIPPON ZEON CO., LTD.

  公开号：EP0435264A1

  公开（公告）日：1991-07-03

  According to this invention, there are provided a binder containing a polyurethane resin having an urethane bond and formed by the reaction of a diisocyanate and a polyol, said resin containing on the average at least 2.3 isocyanate groups in a molecule, having a number average molecular weight of at least 2,000 but at most 10,000 and containing less than 20 % of a component having a molecular weight of at most 1,000; a magneric recording layer or back coat layer using same; and a magnetic recording medium having same. Said magnetic recording medium is excellent in magnetic characteristics, durability and running property.

  根据本发明，提供了一种含有聚氨酯树脂的粘结剂，该聚氨酯树脂具有聚氨酯键，由二异氰酸酯和多元醇反应形成，所述树脂分子中平均含有至少 2.3 个异氰酸酯基团，平均分子量至少为 2,000 但最多为 10,000，分子量最多为 1,000 的成分含量低于 20%；使用该粘结剂的磁记录层或背层；以及使用该粘结剂的磁记录介质。所述磁记录介质具有优异的磁性、耐用性和运行性能。
• Binder for coating materials containing dispersed inorganic powder, coating material containing dispersed inorganic powder, and magnetic recording medium
  申请人：NIPPON ZEON CO., LTD.

  公开号：EP0673956A1

  公开（公告）日：1995-09-27

  A binder for coating materials containing dispersed inorganic powder comprises a polyurethane resin containing (a) 2.2 to 7.0 terminal epoxy groups in one molecule in average and (b) 0.1 to 5.0 % by weight as SO₃⁻ of a sulfonic acid salt group, 0.05 to 3.0 % by weight as COO⁻ of a carboxylic acid salt group, or 0.02 to 1.0 % by weight as N⁺ of a quaternary ammonium salt group in the molecule, and having a number-average molecular weight of 2,000 to 10,000. A coating material containing dispersed inorganic powder and a magnetic recording medium both use this binder. In a recording medium comprising a magnetic layer placed on a non-magnetic substrate, the magnetic layer comprises polyurethane resin (A) as a binder, vinyl chloride polymer (B) containing 0.1 to 20 % by weight of epoxy group and having an average degree of polymerization of 100 to 500, as another binder, (C) an alicylic acid anhydride as a crosslinking agent, and (E) a tertiary amine as a catalyst, and at least one of the binders is crosslinked between the epoxy groups therein by the reaction in which components (C) and (E) take part. The coating material containing fine inorganic powder dispersed with stability and having a low viscosity can be obtained by using, as the binder, the polyurethane resin having terminal epoxy groups and one of a sulfonic acid salt group, a carboxylic acid salt group, and a quaternary ammonium salt group. The magnetic recording material prepared by using magnetic powder as the inorganic powder and crosslinking the binder is excellent in dispersion of the magnetic powder and smoothness of the surface. Therefore, the magnetic recording medium is excellent in magnetic properties, durability, and running properties.

  一种用于含有分散无机粉末的涂层材料的粘结剂包括一种聚氨酯树脂，该树脂含有 (a) 一个分子中平均 2.2 至 7.0 个末端环氧基团和 (b) 以重量计 0.1 至 5.0 % 的磺酸盐基 SO₃-、0.05至3.0%(以重量计)的羧酸盐基COO-，或0.02至1.0%(以重量计)的季铵盐基N⁺，其平均分子量为2,000至10,000。含有分散无机粉末的涂层材料和磁性记录介质都使用这种粘合剂。在一种记录介质中，包括置于非磁性基底上的磁性层，磁性层包括作为粘合剂的聚氨酯树脂 (A)、氯乙烯聚合物 (B)、含有 0.(C) 作为交联剂的水杨酸酐，和 (E) 作为催化剂的叔胺，并且至少有一种粘合剂通过组分 (C) 和 (E) 参与的反应在其中的环氧基团之间交联。使用具有末端环氧基团和磺酸盐基团、羧酸盐基团和季铵盐基团之一的聚氨酯树脂作为粘合剂，可以获得含有分散稳定且粘度低的细小无机粉末的涂层材料。使用磁性粉末作为无机粉末并交联粘合剂制备的磁记录材料在磁性粉末的分散性和表面光滑度方面都非常出色。因此，磁记录介质在磁性能、耐用性和运行性能方面都非常出色。
• An orally administered drug form comprising a glycosidic antibiotic and an adjuvant
  申请人：INTERx RESEARCH CORPORATION

  公开号：EP0035770B1

  公开（公告）日：1986-12-30