(1,1-dioxo-1λ⁶-benzo[b]thiophen-4-yl)-acetic acid | 102539-83-3

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: (1,1-dioxo-1λ⁶-benzo[b]thiophen-4-yl)-acetic acid
• 英文别名: (1,1-Dioxo-1λ⁶-benzo[b]thiophen-4-yl)-essigsaeure；4-carboxymethyl-1,1-dioxidebenzo[b]thiophene；Benzo[b]thiophene-4-acetic acid, 1,1-dioxide；2-(1,1-dioxo-1-benzothiophen-4-yl)acetic acid
• CAS: 102539-83-3
• 化学式: C₁₀H₈O₄S
• 分子量: 224.237
• InChiKey: UMPVJQJFHXABJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  benzothiophene-4-acetic acid 在 双氧水 、 溶剂黄146 作用下， 生成 (1,1-dioxo-1λ⁶-benzo[b]thiophen-4-yl)-acetic acid
  参考文献：
  名称：

  Synthesis of 4-Substituted Thianaphthene Derivatives

  摘要：

  DOI：

  10.1021/jo50017a009

文献信息

• Fused thiophone derivatives and drugs containing the same as the active ingredient
  申请人：——

  公开号：US20030073706A1

  公开（公告）日：2003-04-17

  The present invention relates to a fused thiophene derivative of the formula (I) (wherein all the symbols are defined as described in the specification) and an inhibitor of producing interleukin-6 and/or interleukin-12 comprising the said derivative as an active ingredient. A fused thiophene derivative of the formula (I) is useful as an agent for the prevention and/or treatment of various inflammatory diseases, sepsis, multiple myeloma, plasma cell leukemia, osteoporosis, cachexia, psoriasis, nephritis, renal cell carcinoma, Kaposi's sarcoma, rheumatoid arthritis, gammopathy, Castleman's disease, atrial myxoma, diabetes mellitus, autoimmune diseases, hepatitis, multiple sclerosis, colitis, graft versus host immune diseases, infectious diseases. 1

  本发明涉及公式（I）的融合噻吩衍生物（其中所有符号如规范中所述）和一种抑制产生白细胞介素-6和/或白细胞介素-12的抑制剂，其包含所述衍生物作为活性成分。公式（I）的融合噻吩衍生物可用作预防和/或治疗各种炎症性疾病、败血症、多发性骨髓瘤、浆细胞白血病、骨质疏松症、消瘦症、银屑病、肾炎、肾细胞癌、卡波西肉瘤、类风湿性关节炎、免疫球蛋白病、卡斯特曼病、心房黏液瘤、糖尿病、自身免疫疾病、肝炎、多发性硬化症、结肠炎、移植物抗宿主免疫疾病、传染病的药剂。
• FUSED THIOPHENE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1067128A1

  公开（公告）日：2001-01-10

  Fused thiophene derivatives represented by general formula (I) and interleukin-6 and/or interleukin-12 production inhibitors containing these derivatives as the active ingredient (in general formula (I), each symbol has the meaning as defined in the specification). The fused thiophene derivatives represented by general formula (I) are useful as preventives and/or remedies for various inflammatory diseases, sepsis, multiple myeloma, plasma cell leukemia, osteoporosis, cachexia, psoriasis, nephritis, renal cell cancer, Kaposi's sarcoma, chronic rheumatoid arthritis, hypergamma-globulinemia, Curschmann's disease, intraartial myxoma, diabetes, autoimmune diseases, hepatitis, multiple sclerosis, colon inflammation, graft-versus-host disease and infectious diseases.

  通式(I)代表的融合噻吩衍生物和含有这些衍生物作为活性成分的白细胞介素-6和/或白细胞介素-12产生抑制剂（在通式(I)中，每个符号的含义如说明书中所定义）。通式（I）所代表的融合噻吩衍生物可作为各种炎症、败血症、多发性骨髓瘤、浆细胞白血病、骨质疏松症、恶病质、牛皮癣、肾炎、肾细胞癌的预防和/或治疗药物、卡波西肉瘤、慢性类风湿性关节炎、高丙种球蛋白血症、库希曼病、关节内肌瘤、糖尿病、自身免疫性疾病、肝炎、多发性硬化症、结肠炎、移植物抗宿主病和传染病。
• US6420391B1
  申请人：——

  公开号：US6420391B1

  公开（公告）日：2002-07-16
• US6555555B1
  申请人：——

  公开号：US6555555B1

  公开（公告）日：2003-04-29
• Synthesis of 4-Substituted Thianaphthene Derivatives
  作者：Milton C. Kloetzel、Jess E. Little、David M. Frisch

  DOI：10.1021/jo50017a009

  日期：1953.11