7-Hydroxycoumarinyl Arachidonate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-Hydroxycoumarinyl Arachidonate
• 英文别名: (2-oxochromen-7-yl) (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
• 化学式: C₂₉H₃₆O₄
• 分子量: 448.6
• InChiKey: SFTGFGOBCQCZDY-DOFZRALJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  33
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from Acacia
  申请人：UNIGEN PHARMACEUTICALS, INC.

  公开号：US20030180402A1

  公开（公告）日：2003-09-25

  The present invention provides a novel method for simultaneously inhibiting the cyclooxygenase COX-2 and 5-lipoxygenase (5-LO) enzymes. The method for the simultaneous dual inhibition of COX-2 and 5-LO is comprised of administering a composition containing an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 and 5-LO mediated diseases and conditions. The method for preventing and treating COX-2 and 5-LO mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition comprising an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants and a pharmaceutically acceptable carrier. The present invention includes a method for isolating and purifying a composition of flavans having dual specificity for COX-2 and 5-LO from the Acacia genus of plants.

  本发明提供了一种同时抑制环氧化酶COX-2和5-脂氧合酶（5-LO）的新方法。同时双重抑制 COX-2 和 5-LO 的方法包括向有需要的宿主施用一种组合物，该组合物含有从金合欢属植物中的一种植物或多种植物中分离出来的单个黄酮和/或多种黄酮的混合物。本发明还包括预防和治疗 COX-2 和 5-LO 介导的疾病和病症的新方法。预防和治疗COX-2和5-LO介导的疾病和病症的方法包括向有需要的宿主施用有效量的组合物，该组合物包含从金合欢属植物中的单个植物或多个植物中分离的单个黄素和/或多个黄素的混合物以及药学上可接受的载体。本发明包括一种从金合欢属植物中分离和纯化对COX-2和5-LO具有双重特异性的黄素组合物的方法。
• ISOLATION OF A DUAL COX-2 AND 5-LIPOXYGENASE INHIBITOR FROM ACACIA
  申请人：Unigen Pharmaceuticals, Inc.

  公开号：EP1490081A1

  公开（公告）日：2004-12-29
• EP1490081A4
  申请人：——

  公开号：EP1490081A4

  公开（公告）日：2006-04-12
• METHODS OF PREPARATION OF RECOMBINANT FORMS OF HUMAN BETA-AMYLOID PROTEIN AND USES OF THESE PROTEINS
  申请人：ABBOTT LABORATORIES

  公开号：EP1963363A2

  公开（公告）日：2008-09-03
• Isolation of a Dual Cox-2 and 5-Lipoxygenase Inhibitor from Acacia
  申请人：Jia Qi

  公开号：US20060269627A1

  公开（公告）日：2006-11-30

  The present invention provides a novel method for simultaneously inhibiting the cyclooxygenase COX-2 and 5-lipoxygenase (5-LO) enzymes. The method for the simultaneous dual inhibition of COX-2 and 5-LO is comprised of administering a composition containing an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 and 5-LO mediated diseases and conditions. The method for preventing and treating COX-2 and 5-LO mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition comprising an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants and a pharmaceutically acceptable carrier. The present invention includes a method for isolating and purifying a composition of flavans having dual specificity for COX-2 and 5-LO from the Acacia genus of plants.