7-[Bis[(4-fluorophenyl)methyl]amino]-2-oxochromene-3-carboxylic acid | 1448314-02-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-[Bis[(4-fluorophenyl)methyl]amino]-2-oxochromene-3-carboxylic acid
• CAS: 1448314-02-0
• 化学式: C₂₄H₁₇F₂NO₄
• 分子量: 421.4
• InChiKey: QIMUJZXUWHPQCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• THERAPEUTIC COMPOUNDS
  申请人：Regents of the University of Minnesota

  公开号：US20140371272A1

  公开（公告）日：2014-12-18

  The invention provides compounds of formula (I) or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula (I) and therapeutic methods for treating cancer or treating autoimmune diseases or preventing transplant rejection using compounds of formula (I).
• US9296728B2
  申请人：——

  公开号：US9296728B2

  公开（公告）日：2016-03-29
• US9573888B2
  申请人：——

  公开号：US9573888B2

  公开（公告）日：2017-02-21
• [EN] THERAPEUTIC COMPOUNDS<br/>[FR] COMPOSÉS THÉRAPEUTIQUES
  申请人：UNIV MINNESOTA

  公开号：WO2013109972A2

  公开（公告）日：2013-07-25

  The invention provides compounds of formula (I) or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula (I) and therapeutic methods for treating cancer or treating autoimmune diseases or preventing transplant rejection using compounds of formula (I).